Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

As a key component of the inflammasome, NLRP3 is a critical intracellular danger sensor
emerging as an important clinical target in inflammatory diseases. However, little is known …

The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …

Whereas some rare lipids contribute to the identity of cell organelles, we focus on the
abundant lipids that form the matrix of organelle membranes. Observations using bioprobes …

Inositol phospholipids have long been known to have an important regulatory role in cell
physiology. The repertoire of cellular processes known to be directly or indirectly controlled …

Polyphosphoinositides are an important class of lipid that recruit specific effector proteins to
organelle membranes. One member, phosphatidylinositol 4-phosphate (PtdIns4 P) has …

Genetic and biochemical analyses of the secretory pathway have produced a detailed
picture of the molecular mechanisms involved in selective cargo transport between …

The ADP-ribosylation factor (ARF) small GTPases regulate vesicular traffic and organelle
structure by recruiting coat proteins, regulating phospholipid metabolism and modulating the …

Lysosomes are composed of soluble and transmembrane proteins that are targeted to
lysosomes in a signal-dependent manner. The majority of soluble acid hydrolases are …