Selective androgen receptor modulators (SARMs) are small molecule drugs that function as
either androgen receptor (AR) agonists or antagonists. Variability in AR regulatory proteins …

The androgen receptor (AR) plays a key role in the maintenance of muscle and bone and
the support of male sexual-related functions, as well as in the progression of prostate …

Interest in the development and therapeutic potential of nonsteroidal tissue-selective
androgen receptor modulators (SARMs) a has increased dramatically within the past …

Kurkumin merupakan suatu kandungan dari Curcuma longa L. yang telah dibuktikan efek
sitotoksiknya secara in vitro terhadap sel kanker prostat. Penelitian ini bertujuan untuk …

An empirical correlation between the fluorine isotropic chemical shifts, measured by 19F
NMR spectroscopy, and the type of fluorine–protein interactions observed in crystal …

In our effort to find small-molecule treatments of advanced prostate cancers (PCs), a novel
series of indolyl and indolinyl propanamides (series II and III) were discovered as selective …

The estimation of the correct binding mode and affinity of a ligand into a target protein using
computational methods is challenging. However, docking can introduce poses from which …

A novel selective androgen receptor modulator scaffold has been discovered through
structural modifications of hydantoin antiandrogens. Several 4-(4-hydroxyphenyl)-N …

Osteoporosis is a common disease in which the risk of fracture increases due to decreased
bone mass and qualitative skeletal changes. Selective androgen receptor modulators …

We have discovered a novel class of nonsteroidal pyrazoline antagonists of the
mineralocorticoid receptor (MR) that show excellent potency and selectivity against other …