An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …

Approximately 6% of adults worldwide have atherosclerosis and thrombosis of the lower
limb arteries (peripheral artery disease (PAD)) and the prevalence is rising. PAD causes leg …

The complex pathobiology underlying cardiovascular diseases (CVDs) has yet to be
explained. Aberrant epigenetic changes may result from alterations in enzymatic activities …

Peripheral arterial disease (PAD) of the lower extremities is a chronic illness predominantly
of atherosclerotic aetiology, associated to traditional cardiovascular (CV) risk factors. It is …

Background: Few effective therapies exist to improve lower extremity muscle pathology and
mobility loss due to peripheral artery disease (PAD), in part because mechanisms …

Objective—In response to tissue injury, the appropriate progression of events in
angiogenesis is controlled by a careful balance between pro and antiangiogenic factors. We …

Critical limb ischemia (CLI) constitutes the most severe form of peripheral arterial disease
(PAD), it is characterized by progressive blockade of arterial vessels, commonly correlated …

Introduction It is widely acknowledged that cardiovascular diseases (CVDs) continue to be
the leading cause of death globally. Furthermore, CVDs are the leading cause of diminished …

Reactive oxygen and nitrogen species (ROS and RNS, eg H 2 O 2, nitric oxide) confer redox
regulation of essential cellular signaling pathways such as cell differentiation, proliferation …

The diagnosis of peripheral arterial disease (PAD) is not always evident as symptoms and
signs may show great variation. As all grades of PAD are linked to both an increased risk for …