Background: In preconception and pregnancy, women are encouraged to take folic acid-
based supplements over and above food intake. The upper tolerable limit of folic acid is …

Purpose: To evaluate the effect of folate and folate plus zinc supplementation on endocrine
parameters and sperm characteristics in sub fertile men. Materials and Methods: We …

Background and Objectives Methylenetetrahydrofolate reductase (MTHFR) polymorphism
may be a risk factor for male infertility. However, the epidemiologic studies showed …

STUDY QUESTION Is the methylation status of the methylenetetrahydrofolate reductase
(MTHFR) promoter region in semen samples associated with 'recurrent spontaneous …

Balanced diet is the natural source of micronutrients, such as folate and vitamins, vital for
proper functioning of the body. One-carbon metabolic pathway along with folate and other …

Background Epidemiological studies have reported that polymorphisms of folate-
metabolizing genes have a significant impact on male infertility. However, the results of …

Several studies showed that the genetic mutations in the folate-related enzyme genes might
be associated with male infertility; however, the results were still inconsistent. We performed …

Causes of autism are still unknown. Some studies have shown that autism might be
associated with metabolic abnormalities in the folate/homocysteine pathway, which is …

Folate pathway is expected to play an important role in spermatogenesis since it is involved
in DNA synthesis, repair and methylation. The purpose of this study was to examine the …

The methylenetetrahydrofolate reductase (MTHFR) gene codes a crucial enzyme which
involve in folate metabolism. The effect of MTHFR gene polymorphisms on male fertility …