Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms

D Ezhilarasan - Toxicology, 2021 - Elsevier
Methotrexate (MTX) is one of the most effective and widely used drugs in the management of
autoimmune and dermatological diseases. Rheumatoid arthritis and psoriasis patients who …

Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications

R Das, MS Lami, AJ Chakraborty… - Evidence‐Based …, 2022 - Wiley Online Library
Ginkgo biloba is an ancient plant species that is thought to provide a variety of health
benefits to living organisms and contains plenty of bioactive components, making it a …

Drug-induced liver injury and anti-hepatotoxic effect of herbal compounds: A metabolic mechanism perspective

J Rani, SB Dhull, PK Rose, MK Kidwai - Phytomedicine, 2024 - Elsevier
Background Drug-induced liver injury (DILI) is the most challenging and thought-provoking
liver problem for hepatologists owing to unregulated medication usage in medical practices …

Busting the myth of methotrexate chronic hepatotoxicity

V Di Martino, DW Verhoeven, F Verhoeven… - Nature Reviews …, 2023 - nature.com
Methotrexate is a key component of the treatment of inflammatory rheumatic diseases and
the mainstay of therapy in rheumatoid arthritis. Hepatotoxicity has long been a concern for …

Carveol Attenuates Seizure Severity and Neuroinflammation in Pentylenetetrazole‐Kindled Epileptic Rats by Regulating the Nrf2 Signaling Pathway

AM Alvi, LT Al Kury, A Alattar, I Ullah… - Oxidative medicine …, 2021 - Wiley Online Library
Epilepsy is a neurodegenerative brain disorder characterized by recurrent seizure attacks.
Numerous studies have suggested a strong correlation between oxidative stress and …

Carvacrol alleviates hyperuricemia-induced oxidative stress and inflammation by modulating the NLRP3/NF-κB pathwayt

M Riaz, LT Al Kury, N Atzaz, A Alattar… - Drug design …, 2023 - Taylor & Francis
Purpose Gouty arthritis is generally induced by the accumulation of monosodium urate
(MSU) crystals in the joints due to elevated serum uric acid levels, potentially leading to …

[PDF][PDF] RETRACTED ARTICLE: Natural Dietary Supplement, Carvacrol, Alleviates LPS-Induced Oxidative Stress, Neurodegeneration, and Depressive-Like Behaviors …

K Naeem, L Tariq Al Kury, F Nasar… - Journal of …, 2021 - Taylor & Francis
Naeem K, Tariq Al Kury L, Nasar F, et al. J Inflamm Res. 2021; 14: 1313–1329. At the
authors request, the Editor and Publisher of Journal of Inflammation Research wish to retract …

Alpha-linolenic acid impedes cadmium-induced oxidative stress, neuroinflammation, and neurodegeneration in mouse brain

SI Alam, MW Kim, FA Shah, K Saeed, R Ullah, MO Kim - Cells, 2021 - mdpi.com
Alpha-Linolenic acid (ALA), an omega-3 polyunsaturated fatty acid, is extracted from plant
sources and has been shown to be one of the anti-inflammatory and antioxidant agents …

Hepatoprotective effect of Ginkgo biloba extract against methotrexate-induced hepatotoxicity via targeting STAT3/miRNA-21 axis

IO Sherif, NH Al-Shaalan - Drug and chemical toxicology, 2022 - Taylor & Francis
The usage of the chemotherapeutic agent methotrexate (MTX) was associated with
hepatotoxicity that minimized its clinical use. The Ginkgo biloba extract (GBE) was used …

The Protective Effects of Nutraceutical Components in Methotrexate-Induced Toxicity Models—An Overview

GE Marin, MA Neag, CC Burlacu, AD Buzoianu - Microorganisms, 2022 - mdpi.com
There are multiple concerns associated with methotrexate (MTX), widely recognized for anti-
neoplastic and anti-inflammatory effects in life-threatening disease conditions, ie, acute …