Tuberculosis is primarily a disease of the lung, and dissemination of the disease depends
on productive infection of this critical organ. Upon aerosol infection with Mycobacterium …

Tuberculosis (TB) vaccine research has reached a unique point in time. Breakthrough
findings in both the basic immunology of Mycobacterium tuberculosis infection and the …

Th1 cells are critical for containment of Mycobacterium tuberculosis infection, but little else is
known about the properties of protective CD4 T cell responses. In this study, we show that …

Classically naïve CD4+ have been thought to differentiate into two possible lineages, T
helper 1 (Th1) or T helper 2 (Th2) cells. Within this paradigm the pathogenesis of …

The tuberculosis (TB) pandemic continues to rampage despite widespread use of the BCG
(Bacillus Calmette–Guérin) vaccine. Novel vaccination strategies are urgently needed to …

Tuberculosis (TB) remains a global health problem. The solution involves development of an
effective vaccine, but has been limited by incomplete understanding of what constitutes …

The vaccine discovery paradigm in tuberculosis (TB) has been to mimic the natural immune
response to infection. With an emphasis on interferon (IFN)-γ as the main protective …

Immunological memory provides the basis for successful vaccines. It is important to
understand the properties of memory cells. There is much known about the phenotype and …

Rationale: Although it is well recognized that CD4+ T cells and T helper (Th) 1 cytokines are
critical in the cell-mediated response to Mycobacterium tuberculosis, it is also clear that this …

Background. New vaccines against tuberculosis (TB) are urgently needed because the only
available vaccine, Mycobacterium bovis bacillus Calmette-Guérin (BCG), fails to protect …