Staphylococcal biofilm development: structure, regulation, and treatment strategies

K Schilcher, AR Horswill - Microbiology and Molecular Biology …, 2020 - Am Soc Microbiol
In many natural and clinical settings, bacteria are associated with some type of biotic or
abiotic surface that enables them to form biofilms, a multicellular lifestyle with bacteria …

Regulation of Staphylococcus aureus Virulence

C Jenul, AR Horswill - Microbiology spectrum, 2019 - Am Soc Microbiol
Staphylococcus aureus is a Gram-positive opportunistic pathogen that has evolved a
complex regulatory network to control virulence. One of the main functions of this …

Recent advances in anti-virulence therapeutic strategies with a focus on dismantling bacterial membrane microdomains, toxin neutralization, quorum-sensing …

O Fleitas Martínez, MH Cardoso, SM Ribeiro… - Frontiers in cellular …, 2019 - frontiersin.org
Antimicrobial resistance constitutes one of the major challenges facing humanity in the
Twenty-First century. The spread of resistant pathogens has been such that the possibility of …

Commensal staphylococci influence Staphylococcus aureus skin colonization and disease

CP Parlet, MM Brown, AR Horswill - Trends in microbiology, 2019 - cell.com
Commensal organisms that constitute the skin microbiota play a pivotal role in the
orchestration of cutaneous homeostasis and immune competence. This balance can be …

New perspectives on the use of phytochemicals as an emergent strategy to control bacterial infections including biofilms

A Borges, AC Abreu, C Dias, MJ Saavedra, F Borges… - Molecules, 2016 - mdpi.com
The majority of current infectious diseases are almost untreatable by conventional antibiotic
therapy given the advent of multidrug-resistant bacteria. The degree of severity and the …

Coagulase-negative staphylococcal strain prevents Staphylococcus aureus colonization and skin infection by blocking quorum sensing

AE Paharik, CP Parlet, N Chung, DA Todd… - Cell host & …, 2017 - cell.com
Coagulase-negative staphylococci (CoNS) and Staphylococcus aureus are part of the
natural flora of humans and other mammals. We found that spent media from the CoNS …

Thinking outside the box—novel antibacterials to tackle the resistance crisis

M Lakemeyer, W Zhao, FA Mandl… - Angewandte Chemie …, 2018 - Wiley Online Library
The public view on antibiotics as reliable medicines changed when reports about “resistant
superbugs” appeared in the news. While reasons for this resistance development are easily …

Targeting ESKAPE pathogens with anti-infective medicinal plants from the Greater Mpigi region in Uganda

F Schultz, G Anywar, H Tang, F Chassagne, JT Lyles… - Scientific Reports, 2020 - nature.com
Antibiotic resistance poses one of the greatest threats to global health today; conventional
drug therapies are becoming increasingly inefficacious and limited. We identified 16 …

Critical Assessment of the Prospects of Quorum-Quenching Therapy for Staphylococcus aureus Infection

M Otto - International Journal of Molecular Sciences, 2023 - mdpi.com
Staphylococcus aureus is an important pathogen that causes a high number of infections
and is one of the leading causes of death in hospitalized patients. Widespread antibiotic …

Dietary inclusion of chestnut (Castanea sativa) polyphenols to Nile tilapia reared in biofloc technology: Impacts on growth, immunity, and disease resistance against …

H Van Doan, SH Hoseinifar, TQ Hung… - Fish & Shellfish …, 2020 - Elsevier
A feeding trial was carried out to examine the effects of adding chestnut (Castanea sativa)
polyphenols (CSP) on the growth, skin mucus and serum immune parameters of Nile tilapia …