Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies
I Lurje, NT Gaisa, R Weiskirchen, F Tacke - Molecular Aspects of Medicine, 2023 - Elsevier
Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological
wound healing response and can occur in various organs such as the heart, lung, liver …
wound healing response and can occur in various organs such as the heart, lung, liver …
Pulmonary hypertension associated with lung disease: new insights into pathomechanisms, diagnosis, and management
Patients with chronic lung diseases, particularly interstitial lung disease and chronic
obstructive pulmonary disease, frequently develop pulmonary hypertension, which results in …
obstructive pulmonary disease, frequently develop pulmonary hypertension, which results in …
Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19
M Ackermann, SE Verleden, M Kuehnel… - … England Journal of …, 2020 - Mass Medical Soc
Background Progressive respiratory failure is the primary cause of death in the coronavirus
disease 2019 (Covid-19) pandemic. Despite widespread interest in the pathophysiology of …
disease 2019 (Covid-19) pandemic. Despite widespread interest in the pathophysiology of …
Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation
Numerous reports of vascular events after an initial recovery from COVID-19 form our
impetus to investigate the impact of COVID-19 on vascular health of recovered patients. We …
impetus to investigate the impact of COVID-19 on vascular health of recovered patients. We …
Circulating Von Willebrand factor and high molecular weight multimers as markers of endothelial injury predict COVID-19 in-hospital mortality
Abstract Background Coronavirus disease 2019 (COVID-19) is a respiratory disease
associated with endotheliitis and microthrombosis. Objectives To correlate endothelial …
associated with endotheliitis and microthrombosis. Objectives To correlate endothelial …
Effect of atmospheric aging on soot particle toxicity in lung cell models at the air–liquid interface: differential toxicological impacts of biogenic and anthropogenic …
S Offer, E Hartner, S Di Bucchianico… - Environmental …, 2022 - ehp.niehs.nih.gov
Background: Secondary organic aerosols (SOAs) formed from anthropogenic or biogenic
gaseous precursors in the atmosphere substantially contribute to the ambient fine particulate …
gaseous precursors in the atmosphere substantially contribute to the ambient fine particulate …
IL-4/IL-13 remodeling pathway of COVID-19 lung injury
CB Vaz de Paula, MLV de Azevedo, S Nagashima… - Scientific Reports, 2020 - nature.com
The COVID-19 fatality rate is high when compared to the H1N1pdm09 (pandemic Influenza
A virus H1N1 subtype) rate, and although both cause an aggravated inflammatory response …
A virus H1N1 subtype) rate, and although both cause an aggravated inflammatory response …
Inflammation and vascular remodeling in COVID-19 hearts
A wide range of cardiac symptoms have been observed in COVID-19 patients, often
significantly influencing the clinical outcome. While the pathophysiology of pulmonary …
significantly influencing the clinical outcome. While the pathophysiology of pulmonary …
Endothelial cell plasticity at the single-cell level
A Pasut, LM Becker, A Cuypers, P Carmeliet - Angiogenesis, 2021 - Springer
The vascular endothelium is characterized by a remarkable level of plasticity, which is the
driving force not only of physiological repair/remodeling of adult tissues but also of …
driving force not only of physiological repair/remodeling of adult tissues but also of …
[HTML][HTML] Covid-19, angiogenesis, and ARDS endotypes
L Hariri, CC Hardin - New England Journal of Medicine, 2020 - Mass Medical Soc
The SARS-CoV-2 pandemic has inspired new interest in understanding the fundamental
pathology of acute respiratory distress syndrome (ARDS), which has been associated with …
pathology of acute respiratory distress syndrome (ARDS), which has been associated with …