Caspase-9, a cysteine-aspartic protease known for its role as an initiator of intrinsic
apoptosis, regulates physiological cell death and pathological tissue degeneration. Its …

Caspases are proteases at the heart of networks that govern apoptosis and inflammation.
The past decade has seen huge leaps in understanding the biology and chemistry of the …

Invasive pulmonary aspergillosis is a leading cause of infection-associated mortality in
immunocompromised individuals. Aspergillus fumigatus infection produces ligands that …

The clinical challenge posed by p53 abnormalities in hematological malignancies requires
therapeutic strategies other than standard genotoxic chemotherapies. ONC201 is a first-in …

We recently reported that P2X7 receptor (P2X7R)-induced activation of caspase-1
inflammasomes is accompanied by release of MHC class II (MHC-II) protein into …

Many biologically and chemically based approaches have been developed to design highly
active and selective protease substrates and probes. It is, however, difficult to find substrate …

Retinal ganglion cells (RGC) are terminally differentiated CNS neurons that possess limited
endogenous regenerative capacity after injury and thus RGC death causes permanent …

Inflammasomes are protein complexes induced by diverse inflammatory stimuli that activate
caspase-1, resulting in the processing and release of cytokines, IL-1β and IL-18, and …

Inflammation induced by hypoxia–ischemia (HI) contributes to the development of injury in
the newborn brain. In this study, we investigated the role of galectin-3, a novel inflammatory …

Caspases are proteases of clan CD and were described for the first time more than two
decades ago. They play critical roles in the control of regulated cell death pathways …