Most clinically applied cancer immunotherapies rely on the ability of CD8+ cytolytic T cells to
directly recognize and kill tumour cells,–. These strategies are limited by the emergence of …

Loss-of-function mutations in Angiopoietin-like 3 (Angptl3) are associated with lowered
blood lipid levels, making Angptl3 an attractive therapeutic target for the treatment of human …

The CRISPR/Cas9 system has enabled efficient modification of genes in a variety of cellular
systems for studying phenotypic effects of genetic perturbations. However, with this …

The NLRP3 inflammasome plays a central role in antimicrobial defense as well as in the
context of sterile inflammatory conditions. NLRP3 activity is governed by two independent …

Abstract Cyclic GMP–AMP synthase (cGAS) is an innate immune sensor for cytosolic
microbial DNA. After binding DNA, cGAS synthesizes the messenger 2′ 3′-cyclic GMP …

Detection of cytosolic DNA constitutes a central event in the context of numerous infectious
and sterile inflammatory conditions. Recent studies have uncovered a bipartite mode of …

Purpose: The antibody–drug conjugate enfortumab vedotin (EV) releases a cytotoxic agent
into tumor cells via binding to the membrane receptor NECTIN-4. EV was recently approved …

Summary Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of
the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete …

Cytosolic DNA arising from intracellular pathogens triggers a powerful innate immune
response,. It is sensed by cyclic GMP–AMP synthase (cGAS), which elicits the production of …

Neutrophil extracellular traps (NETs) are structures consisting of chromatin and antimicrobial
molecules that are released by neutrophils during a form of regulated cell death called …