Cardiovascular diseases have become the leading cause of human death. Aging is an
independent risk factor for cardiovascular diseases. Cardiac aging is associated with …

The heart requires fatty acids to maintain its activity. Various mechanisms regulate
myocardial fatty acid metabolism, such as energy production using fatty acids as fuel, for …

The incidence of diabetes is increasing globally, with cardiovascular disease accounting for
a substantial number of diabetes-related deaths. Although atherosclerotic vascular disease …

Aims The endothelial glycocalyx (eGC), a carbohydrate-rich layer lining the luminal surface
of the endothelium, provides a first vasoprotective barrier against vascular leakage and …

The maintenance of whole-body glucose homeostasis is critical for survival, and is
controlled by the coordination of multiple organs and endocrine systems. Pancreatic islet β …

The extracellular matrix (ECM) is a structural framework that has many important
physiological functions which include maintaining tissue structure and integrity, serving as a …

Worldwide, the prevalence of obesity and diabetes have increased, with heart disease being
their leading cause of death. Traditionally, the management of obesity and diabetes has …

Heparanase is an endoglycosidase that specifically cleaves heparan sulfate side chains of
heparan sulfate proteoglycans. Utilizing an ELISA method capable of detection and …

Tumor metastasis, the leading cause of cancer patients' death, is still insufficiently
understood. While concepts and mechanisms of tumor metastasis are evolving, it is widely …

Insulin secretion by pancreatic islet β cells is critical for glucose homeostasis, and a blunted
β cell secretory response is an early deficit in type 2 diabetes. Here, we uncover a regulatory …