The development of new and effective antibacterial drugs to treat multi-drug resistant (MDR)
bacteria, especially Gram-negative (G− ve) pathogens, is acknowledged as one of the …

Antimicrobial resistance (AMR) is a major public health issue, causing 5 million deaths per
year. Without any action plan, AMR will be in a near future the leading cause of death ahead …

With the impending crisis of antimicrobial resistance, there is an urgent need to develop
novel antimicrobials to combat difficult infections and MDR pathogenic microorganisms …

Despite the growing global crisis caused by antimicrobial drug resistance among
pathogenic bacteria, the number of new antibiotics, especially new chemical class of …

ABSTRACT LFF571 is a novel semisynthetic thiopeptide antibiotic with potent activity
against a variety of Gram-positive pathogens, including Clostridium difficile. In vivo efficacy …

Synthetic small molecular antimicrobial peptidomimetics represent a promising new class of
potential antibiotics due to their membrane-disrupting ability and their decreased propensity …

Clostridium difficile is an anaerobic, Gram-positive pathogen that causes C. difficile infection,
which results in significant morbidity and mortality. The incidence of C. difficile infection in …

Clostridioides difficile infection (CDI) is a major cause of nosocomial diarrhea that is deemed
a global health threat. C. difficile strain BI/NAP1/027 has contributed to the increase in the …

Clostridioides difficile infections (CDIs) are an urgent public health threat worldwide and are
a leading cause of morbidity and mortality in healthcare settings. The increasing incidence …

Clostridioides (formerly Clostridium) difficile is a Gram-positive anaerobic bacterial pathogen
that causes severe gastrointestinal infection in humans. The current chemotherapeutic …