Mitochondria are the source of cellular energy production and are present in different types
of cells. However, their function is especially important for the heart due to the high demands …

Both, DNA and RNA nucleoside modifications contribute to the complex multi-level
regulation of gene expression. Modified bases in tRNAs modulate protein translation rates in …

Wobble uridines (U34) are generally modified in all species. U34 modifications can be
essential in metazoans but are not required for viability in fungi. In this review, we provide an …

Plasmodium falciparum artemisinin (ART) resistance is driven by mutations in kelch-like
protein 13 (PfK13). Quiescence, a key aspect of resistance, may also be regulated by a yet …

GTPBP3 is a highly conserved tRNA modifying enzyme for the biosynthesis of τm5U at the
wobble position of mitochondrial tRNAGlu, tRNAGln, tRNALys, tRNATrp and tRNALeu …

Modifications of transfer RNA (tRNA) have been shown to play critical roles in the
biogenesis, metabolism, structural stability and function of RNA molecules, and the specific …

Sulfuration of uridine 34 in the anticodon of tRNAs is conserved in the three domains of life,
guaranteeing fidelity of protein translation. In eubacteria, it is catalyzed by MnmA-type …

Modifications of transfer RNA (tRNA) have been shown to play critical roles in the
biogenesis, metabolism, structural stability, and function of RNA molecules, and the specific …

Toxoplasmosis caused by the protozoan Toxoplasma gondii is one of the most common
parasitic diseases in humans and almost all warm-blooded animals. Lys, Glu, and Gln …

The existence of SpoU-TrmD (SPOUT) RNA methyltransferase superfamily was first
predicted by bioinformatics. SpoU is the previous name of TrmH, which catalyzes the 2'-O …