Beyond the connectome: how neuromodulators shape neural circuits

CI Bargmann - Bioessays, 2012 - Wiley Online Library
Powerful ultrastructural tools are providing new insights into neuronal circuits, revealing a
wealth of anatomically‐defined synaptic connections. These wiring diagrams are …

Starvation Responses Throughout the Caenorhabditis  elegans Life Cycle

LR Baugh, PJ Hu - Genetics, 2020 - academic.oup.com
Caenorhabditis elegans survives on ephemeral food sources in the wild, and the species
has a variety of adaptive responses to starvation. These features of its life history make the …

Spontaneous behaviour is structured by reinforcement without explicit reward

JE Markowitz, WF Gillis, M Jay, J Wood, RW Harris… - Nature, 2023 - nature.com
Spontaneous animal behaviour is built from action modules that are concatenated by the
brain into sequences,. However, the neural mechanisms that guide the composition of …

[HTML][HTML] Neural signal propagation atlas of Caenorhabditis elegans

F Randi, AK Sharma, S Dvali, AM Leifer - Nature, 2023 - nature.com
Establishing how neural function emerges from network properties is a fundamental problem
in neuroscience. Here, to better understand the relationship between the structure and the …

Whole-animal connectomes of both Caenorhabditis elegans sexes

SJ Cook, TA Jarrell, CA Brittin, Y Wang, AE Bloniarz… - Nature, 2019 - nature.com
Abstract Knowledge of connectivity in the nervous system is essential to understanding its
function. Here we describe connectomes for both adult sexes of the nematode …

Neural circuit policies enabling auditable autonomy

M Lechner, R Hasani, A Amini, TA Henzinger… - Nature Machine …, 2020 - nature.com
A central goal of artificial intelligence in high-stakes decision-making applications is to
design a single algorithm that simultaneously expresses generalizability by learning …

[HTML][HTML] Mapping sub-second structure in mouse behavior

AB Wiltschko, MJ Johnson, G Iurilli, RE Peterson… - Neuron, 2015 - cell.com
Complex animal behaviors are likely built from simpler modules, but their systematic
identification in mammals remains a significant challenge. Here we use depth imaging to …

Global brain dynamics embed the motor command sequence of Caenorhabditis elegans

S Kato, HS Kaplan, T Schrödel, S Skora, TH Lindsay… - Cell, 2015 - cell.com
While isolated motor actions can be correlated with activities of neuronal networks, an
unresolved problem is how the brain assembles these activities into organized behaviors …

Network control principles predict neuron function in the Caenorhabditis elegans connectome

G Yan, PE Vértes, EK Towlson, YL Chew, DS Walker… - Nature, 2017 - nature.com
Recent studies on the controllability of complex systems offer a powerful mathematical
framework to systematically explore the structure–function relationship in biological, social …

Whole-brain serial-section electron microscopy in larval zebrafish

DGC Hildebrand, M Cicconet, RM Torres, W Choi… - Nature, 2017 - nature.com
High-resolution serial-section electron microscopy (ssEM) makes it possible to investigate
the dense meshwork of axons, dendrites, and synapses that form neuronal circuits …