A systematic review of the protective effects of silymarin/silibinin against doxorubicin-induced cardiotoxicity
M Singh, MM Kadhim, A Turki Jalil, SK Oudah… - Cancer Cell …, 2023 - Springer
Purpose Although doxorubicin chemotherapy is commonly applied for treating different
malignant tumors, cardiotoxicity induced by this chemotherapeutic agent restricts its clinical …
malignant tumors, cardiotoxicity induced by this chemotherapeutic agent restricts its clinical …
Herbal nanomedicines: Recent advancements, challenges, opportunities and regulatory overview
Abstract Background Herbal Nano Medicines (HNMs) are nano-sized medicine containing
herbal drugs as extracts, enriched fractions or biomarker constituents. HNMs have certain …
herbal drugs as extracts, enriched fractions or biomarker constituents. HNMs have certain …
Lipid-based delivery systems for flavonoids and flavonolignans: liposomes, nanoemulsions, and solid lipid nanoparticles
Herbal chemicals with a long history in medicine have attracted a lot of attention.
Flavonolignans and flavonoids are considered as two classes of the above-mentioned …
Flavonolignans and flavonoids are considered as two classes of the above-mentioned …
[HTML][HTML] Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
Cancer is identified as second leading causes of death and imposes a significant
psychological and economic burden on societies. Due to its high prevalence, and a main …
psychological and economic burden on societies. Due to its high prevalence, and a main …
[HTML][HTML] Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
Y Wang, AJ Yuan, YJ Wu, LM Wu, L Zhang - Journal of Functional Foods, 2023 - Elsevier
Silymarin, a milk thistle extract, has anti-inflammatory, immunomodulatory, anti-lipid
peroxidative, anti-fibrotic, anti-oxidative, and anti-proliferative properties. Silymarin exhibits …
peroxidative, anti-fibrotic, anti-oxidative, and anti-proliferative properties. Silymarin exhibits …
Annona squamosa L. Extract-Loaded Niosome and Its Anti-Ehrlich Ascites' Carcinoma Activity
AA Abd-Elghany, SM Ahmed, MA Masoud, T Atia… - ACS …, 2022 - ACS Publications
Current research is focused on cancer treatments other than chemotherapy medications,
particularly those derived from natural sources. The goal of this work was to look at the …
particularly those derived from natural sources. The goal of this work was to look at the …
Hepatoprotective effects of silymarin coated gold nanoparticles in experimental cholestasis
The present study reports the green synthesis of hybrid organic-inorganic gold
nanocomposites using silymarin as reducing and capping agent. The structure of the …
nanocomposites using silymarin as reducing and capping agent. The structure of the …
An overview of advanced formulation and nanotechnology-based approaches for solubility and bioavailability enhancement of silymarin
Abstract Approximately 70–80% of drugs in clinical drug development suffer low aqueous
solubility, poor oral bioavailability, and limited intestinal permeability. Flavonoids are a …
solubility, poor oral bioavailability, and limited intestinal permeability. Flavonoids are a …
Niclosamide-loaded polymeric micelles ameliorate hepatocellular carcinoma in vivo through targeting Wnt and Notch pathways
Aim Niclosamide (NIC) is an anthelmintic agent repurposed as a potent anticancer agent.
However, its use is hindered by its poor solubility. We investigated the underlying …
However, its use is hindered by its poor solubility. We investigated the underlying …
Silymarin-loaded tin (IV) nanoparticles exhibit enhanced bioavailability and antiproliferative effects on colorectal cancer cells
Silymarin (SM) exhibits potential therapeutic effects due to having antioxidant activity.
However, the low solubility and bioavailability of SM restrict its biological performance. To …
However, the low solubility and bioavailability of SM restrict its biological performance. To …