The genomic landscape of thyroid cancer tumourigenesis and implications for immunotherapy
A Singh, J Ham, JW Po, N Niles, T Roberts, CS Lee - Cells, 2021 - mdpi.com
Thyroid cancer is the most prevalent endocrine malignancy that comprises mostly indolent
differentiated cancers (DTCs) and less frequently aggressive poorly differentiated (PDTC) or …
differentiated cancers (DTCs) and less frequently aggressive poorly differentiated (PDTC) or …
LncRNA-MIAT promotes thyroid cancer progression and function as ceRNA to target EZH2 by sponging miR-150-5p
K Guo, K Qian, Y Shi, T Sun, Z Wang - Cell death & disease, 2021 - nature.com
While long noncoding RNAs (lncRNAs) have been reported to play an important role in
human cancer types, they remain poorly understood in papillary thyroid carcinoma (PTC) …
human cancer types, they remain poorly understood in papillary thyroid carcinoma (PTC) …
The prevalence of DNA microsatellite instability in anaplastic thyroid carcinoma–systematic review and discussion of current therapeutic options
ML Rocha, KW Schmid, P Czapiewski - Contemporary Oncology …, 2021 - termedia.pl
Results Selected citations revealed the prevalence of MSI in 7.4%, with mutations in the
MSH2 gene (33%) being the most frequent, followed by MSH6 (25%) and MLH1 (16.7%) …
MSH2 gene (33%) being the most frequent, followed by MSH6 (25%) and MLH1 (16.7%) …
Microsatellite instability occurs in a subset of follicular thyroid cancers
LK Genutis, J Tomsic, RA Bundschuh, PL Brock… - Thyroid, 2019 - liebertpub.com
Background: Inactivation of DNA mismatch repair (MMR) and the resulting microsatellite
instability (MSI) are frequently observed in endometrial, stomach, and colorectal cancers, as …
instability (MSI) are frequently observed in endometrial, stomach, and colorectal cancers, as …
MiR-539 inhibits thyroid cancer cell migration and invasion by directly targeting CARMA1
L Gu, W Sun - Biochemical and biophysical research communications, 2015 - Elsevier
MicroRNAs (miRNAs) are important regulators of multiple cellular processes, and aberrant
miRNA expression has been observed in thyroid cancer. However, the role of miRNAs in …
miRNA expression has been observed in thyroid cancer. However, the role of miRNAs in …
MGMT is frequently inactivated in pancreatic NET-G2 and is associated with the therapeutic activity of STZ-based regimens
K Yagi, H Ono, A Kudo, Y Kinowaki, D Asano… - Scientific Reports, 2023 - nature.com
Abstract O6-methylguanine-DNA methyltransferase (MGMT) has been linked with alkylating
agent resistance and tumor growth suppression. However, its role remains undetermined in …
agent resistance and tumor growth suppression. However, its role remains undetermined in …
Long noncoding RNA are aberrantly expressed in human papillary thyroid carcinoma
M Yang, J Tian, X Guo, Y Yang, R Guan… - Oncology …, 2016 - spandidos-publications.com
Long noncoding RNAs (lncRNAs) have emerged as key regulatory molecules at almost
every level of gene expression regulation. The altered expression of lncRNAs is a …
every level of gene expression regulation. The altered expression of lncRNAs is a …
Correlation of mismatch repair deficiency with clinicopathological features and programmed death-ligand 1 expression in thyroid carcinoma
PP Qiao, KS Tian, LT Han, B Ma, CK Shen, RY Zhao… - Endocrine, 2022 - Springer
Background Mutations in DNA mismatch repair (MMR) genes associated with thyroid
carcinoma (TC) have rarely been reported, especially in East Asian populations. Methods …
carcinoma (TC) have rarely been reported, especially in East Asian populations. Methods …
Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer
ML Read, JC Fong, B Modasia, A Fletcher… - Oncogene, 2017 - nature.com
The proto-oncogene PTTG and its binding partner PBF have been widely studied in multiple
cancer types, particularly thyroid and colorectal, but their combined role in tumourigenesis is …
cancer types, particularly thyroid and colorectal, but their combined role in tumourigenesis is …
Mechanisms of therapeutic resistance in cancer (stem) cells with emphasis on thyroid cancer cells
S Hombach-Klonisch, S Natarajan… - Frontiers in …, 2014 - frontiersin.org
The two main reasons for death of cancer patients, tumor recurrence and metastasis, are
multi-stage cellular processes that involve increased cell plasticity and coincide with …
multi-stage cellular processes that involve increased cell plasticity and coincide with …