The UDP-glycosyltransferase (UGT) superfamily: new members, new functions, and novel paradigms
UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …
Emerging roles for UDP-glucuronosyltransferases in drug resistance and cancer progression
EP Allain, M Rouleau, E Lévesque… - British journal of …, 2020 - nature.com
The best-known role of UDP-glucuronosyltransferase enzymes (UGTs) in cancer is the
metabolic inactivation of drug therapies. By conjugating glucuronic acid to lipophilic drugs …
metabolic inactivation of drug therapies. By conjugating glucuronic acid to lipophilic drugs …
Sphingolipids: key regulators of apoptosis and pivotal players in cancer drug resistance
P Giussani, C Tringali, L Riboni, P Viani… - International journal of …, 2014 - mdpi.com
Drug resistance elicited by cancer cells still constitutes a huge problem that frequently
impairs the efficacy of both conventional and novel molecular therapies. Chemotherapy …
impairs the efficacy of both conventional and novel molecular therapies. Chemotherapy …
Glucosylceramide and galactosylceramide, small glycosphingolipids with significant impact on health and disease
S Reza, M Ugorski, J Suchański - Glycobiology, 2021 - academic.oup.com
Numerous clinical observations and exploitation of cellular and animal models indicate that
glucosylceramide (GlcCer) and galactosylceramide (GalCer) are involved in many …
glucosylceramide (GlcCer) and galactosylceramide (GalCer) are involved in many …
Emerging role of metabolomics in ovarian cancer diagnosis
Ovarian cancer is considered a silent killer due to the lack of clear symptoms and efficient
diagnostic tools that often lead to late diagnoses. Over recent years, the impelling need for …
diagnostic tools that often lead to late diagnoses. Over recent years, the impelling need for …
The Expression Profiles and Deregulation of UDP-Glycosyltransferase (UGT) Genes in Human Cancers and Their Association with Clinical Outcomes
Simple Summary The human UDP-glycosyltransferase (UGT) superfamily plays a critical
role in the metabolism of numerous endogenous and exogenous small lipophilic …
role in the metabolism of numerous endogenous and exogenous small lipophilic …
Emerging applications of ultrasound-contrast agents in radiation therapy
Radiation therapy (RT) causes DNA damage through ionization, leading to double-strand
breaks. In addition, it generates reactive oxygen species (ROS), which are toxic to tumor …
breaks. In addition, it generates reactive oxygen species (ROS), which are toxic to tumor …
Regulation of human UDP-glycosyltransferase (UGT) genes by miRNAs
The human UGT gene superfamily is divided into four subfamilies (UGT1, UGT2, UGT3 and
UGT8) that encodes 22 functional enzymes. UGTs are critical for the metabolism and …
UGT8) that encodes 22 functional enzymes. UGTs are critical for the metabolism and …
A new gene expression signature for triple-negative breast cancer using frozen fresh tissue before neoadjuvant chemotherapy
SK Santuario-Facio, S Cardona-Huerta… - Molecular …, 2017 - Springer
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer tumors.
Comparisons between TNBC and non-triple-negative breast cancer (nTNBC) may help to …
Comparisons between TNBC and non-triple-negative breast cancer (nTNBC) may help to …
A novel function for UDP glycosyltransferase 8: galactosidation of bile acids
The human UDP glycosyltransferase (UGT) superfamily comprises four families of enzymes
that catalyze the addition of sugar residues to small lipophilic chemicals. The UGT1 and …
that catalyze the addition of sugar residues to small lipophilic chemicals. The UGT1 and …