Fetal lower urinary tract obstruction (LUTO) is associated with high mortality and postnatal
morbidity caused by lung hypoplasia and impaired kidney function. Specific diagnostic …

Capillary electrophoresis combined with mass spectrometry (CE‐MS) has been used for
several years for the investigation of proteins and peptides as biomarkers for diagnosis and …

In the context of precision medicine, disease treatment requires individualized strategies
based on the underlying molecular characteristics to overcome therapeutic challenges …

Posterior urethral valves (PUV) are the most common form of lower urinary tract obstructions
(LUTO). The valves can be surgically corrected postnatally; however, the impairment of …

Peptides carry important functions in normal physiological and pathophysiological
processes and can serve as clinically useful biomarkers. Given the ability to diffuse …

Kidney research is entering an era of 'big data'and molecular omics data can provide
comprehensive insights into the molecular footprints of cells. In contrast to transcriptomics …

Introduction CKD273 is a urinary biomarker, which in advanced chronic kidney disease
predicts further deterioration. We investigated whether CKD273 can also predict a decline of …

Chronic kidney disease is associated with increased risk of CKD progression and death.
Therapeutic approaches to limit progression are limited. Developing tools for the early …

Urinary peptides gained significant attention as potential biomarkers especially in the
context of kidney and cardiovascular disease. In this manuscript the recent literature since …

Urinary peptidomics focuses on endogenous urinary peptide content. Many studies now
show the usefulness of this approach for the discovery and validation of biomarkers in …