The etiology and pathophysiology genesis of benign prostatic hyperplasia and prostate cancer: a new perspective

TJ Phua - Medicines, 2021 - mdpi.com
Background: The etiology of benign prostatic hyperplasia and prostate cancer are unknown,
with ageing being the greatness risk factor. Methods: This new perspective evaluates the …

Stem cells as target for prostate cancer therapy: opportunities and challenges

C Escudero-Lourdes, I Alvarado-Morales… - Stem cell reviews and …, 2022 - Springer
Cancer stem cells (CSCs) and cells in a cancer stem cell-like (CSCL) state have proven to
be responsible for tumor initiation, growth, and relapse in Prostate Cancer (PCa) and other …

[HTML][HTML] microRNA-497 prevents pancreatic cancer stem cell gemcitabine resistance, migration, and invasion by directly targeting nuclear factor kappa B 1

Q Yu, Z Xiu, Y Jian, J Zhou, X Chen, X Chen… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Objectives: Cancer stem cells (CSCs) comprise a small population of cells in cancerous
tumors and play a critical role in tumor resistance to chemotherapy. miRNAs have been …

[PDF][PDF] The m6A methyltransferase METTL3 promotes the stemness and malignant progression of breast cancer by mediating m6A modification on SOX2

J Xie, J Ba, M Zhang, Y Wan, Z Jin, Y Yao - J buon, 2021 - jbuon.com
Purpose: We aimed to uncover the role of METTL3 in stimulating the stemness and
progression of breast cancer (BCa) through mediating N6-methyladenosine (m6A) …

[HTML][HTML] The combination effect of Prominin1 (CD133) suppression and Oxaliplatin treatment in colorectal cancer therapy

Z Asadzadeh, B Mansoori, A Mohammadi… - Biomedicine & …, 2021 - Elsevier
Colorectal cancer (CRC) is considered one of the leading types of cancer in the world.
CD133, as a cancer stem cell marker, has a pivotal role in the development of drug …

Umbelliprenin induces autophagy and apoptosis while inhibits cancer cell stemness in pancreatic cancer cells

H Wang, Y Liu, Y Wang, T Xu, G Xia… - Cancer Medicine, 2023 - Wiley Online Library
Background Umbelliprenin is a sesquiterpene coumarin isolated from Artemisia absinthium
L. and shows antitumor effects in various cancers by inducing apoptosis. However, the …

Can precancerous stem cells be risk markers for malignant transformation in the oral mucosa?

S Wang, L Ying, SY Yu, J Bai, C Hao - Cellular & Molecular Biology Letters, 2023 - Springer
Accurate assessment of the carcinogenic potential of oral mucosal diseases can significantly
reduce the prevalence of oral cancer. We speculate that precancerous stem cells (pCSCs) …

Cancer Stem Cells and Prostate Cancer: A Narrative Review

Y Al Salhi, MB Sequi, FM Valenzi, A Fuschi… - International Journal of …, 2023 - mdpi.com
Cancer stem cells (CSCs) are a small and elusive subpopulation of self-renewing cancer
cells with the remarkable ability to initiate, propagate, and spread malignant disease. In the …

Tumor architecture and emergence of strong genetic alterations are bottlenecks for clonal evolution in primary prostate cancer

F Kreten, R Büttner, M Peifer, C Harder, AM Hillmer… - Cell Systems, 2024 - cell.com
Prostate cancer (PCA) exhibits high levels of intratumoral heterogeneity. In this study, we
developed a mathematical model to study the growth and genetic evolution of PCA. We …

lncRNA BORG: TRIM28 complexes drive metastatic progression by inducing α6 integrin/CD49f expression in breast cancer stem cells

KA Parker, AJ Gooding, S Valadkhan… - Molecular Cancer …, 2021 - AACR
Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, with its
aggressive phenotype being attributed to chemotherapy resistance, metastatic …