Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

l-Glutamate is the predominant excitatory neurotransmitter in the mammalian central
nervous system and plays important roles in a wide variety of brain functions, but it is also a …

Human members of the solute carrier 1 (SLC1) family of transporters take up excitatory
neurotransmitters in the brain and amino acids in peripheral organs. Dysregulation of the …

Glutamate transporters are integral membrane proteins that catalyse the concentrative
uptake of glutamate from the synapse to intracellular spaces by harnessing pre-existing ion …

Palacı́n, Manuel, Raúl Estévez, Joan Bertran, and Antonio Zorzano. Molecular Biology of
Mammalian Plasma Membrane Amino Acid Transporters. Physiol. Rev. 78: 969–1054, 1998 …

The solute carrier family 1 (SLC1) includes five high-affinity glutamate transporters, EAAC1,
GLT-1, GLAST, EAAT4 and EAAT5 (SLC1A1, SLC1A2, SLC1A3, SLC1A6, and SLC1A7 …

ASCT2 is an obligate exchanger of neutral amino acids, contributing to cellular amino acid
homeostasis. ASCT2 belongs to the same family (SLC1) as Excitatory Amino Acid …

▪ Abstract As the most predominant excitatory neurotransmitter, glutamate has the potential
to influence the function of most neuronal circuits in the central nervous system. To limit …

Excitatory amino acid transporters (EAATs) uptake glutamate into glial cells and neurons.
EAATs achieve million-fold transmitter gradients by symporting it with three sodium ions and …

The solute carrier family 1 (SLC1) is composed of five high affinity glutamate transporters,
which exhibit the properties of the previously described system XAG−, as well as two Na+ …