Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by polymerization
of hemoglobin S upon deoxygenation that results in the formation of rigid sickled-shaped red …

Sickle cell disease and thalassemia are common hereditary blood disorders associated with
increased systemic inflammation, tissue hypoxia, endothelial dysfunction and end-organ …

Persons with sickle cell disease (SCD) exhibit subjective hypersensitivity to cold and heat
perception in experimental settings, and triggers such as cold exposure are known to …

Résumé Sickle cell disease is an inherited hemoglobinopathy caused by a single amino
acid substitution in the β chain of hemoglobin that causes the hemoglobin to polymerize in …

A decreased global autonomic nervous system (ANS) activity and increased sympathetic
activation in patients with sickle cell anemia (SCA) seem to worsen the clinical severity and …

Patients with sickle cell disease (SCD) often experience painful vaso‐occlusive crises and
chronic haemolytic anaemia, as well as various acute and chronic complications, such as …

Fat embolism syndrome (FES) has been described in the literature as a rare complication of
sickle cell disease (SCD). A review article published in 2005 reported 24 cases of FES …

Aims: The aim of this study was to evaluate the ANS by determining the HRV in patients with
SCD during VOC. Settings and Design: This was a cross-sectional observational study …

Sickle cell disease (SCD) is one of the most common hereditary hemoglobinopathies
worldwide. It is a multisystem disease that causes considerable patient morbidity. Despite …

Background: The integrity of the autonomic nervous system (ANS) is essential for keeping
physiological processes stable, even under stress. Since there is growing interest in heart …