Mechanisms of dupilumab
H Harb, TA Chatila - Clinical & Experimental Allergy, 2020 - Wiley Online Library
The Th2 cytokines interleukin 4 (IL‐4) and IL‐13 and the heterodimeric IL‐4 receptor (IL‐4R)
complexes that they interact with play a key role in the pathogenesis of allergic disorders …
complexes that they interact with play a key role in the pathogenesis of allergic disorders …
Pathophysiology of eosinophilic esophagitis
KM O'Shea, SS Aceves, ES Dellon, SK Gupta… - Gastroenterology, 2018 - Elsevier
Eosinophilic esophagitis is an emerging disease that is distinguished from
gastroesophageal reflux disease by the expression of a unique esophageal transcriptome …
gastroesophageal reflux disease by the expression of a unique esophageal transcriptome …
[HTML][HTML] RPC4046, a monoclonal antibody against IL13, reduces histologic and endoscopic activity in patients with eosinophilic esophagitis
I Hirano, MH Collins, Y Assouline-Dayan, L Evans… - Gastroenterology, 2019 - Elsevier
Background & aims Eosinophilic esophagitis (EoE) is a chronic, esophageal, type 2
inflammatory response associated with increased serum levels of interleukin 13 (IL13) …
inflammatory response associated with increased serum levels of interleukin 13 (IL13) …
Calpain research for drug discovery: challenges and potential
Y Ono, TC Saido, H Sorimachi - Nature Reviews Drug Discovery, 2016 - nature.com
Calpains are a family of proteases that were scientifically recognized earlier than
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …
Multifactorial skin barrier deficiency and atopic dermatitis: Essential topics to prevent the atopic march
G Egawa, K Kabashima - Journal of Allergy and Clinical Immunology, 2016 - Elsevier
Atopic dermatitis (AD) is the most common inflammatory skin disease in the industrialized
world and has multiple causes. Over the past decade, data from both experimental models …
world and has multiple causes. Over the past decade, data from both experimental models …
Barrier dysfunction in the skin allergy
G Egawa, K Kabashima - Allergology international, 2018 - jstage.jst.go.jp
abstract The skin is continuously exposed to external pathogens, and its barrier function is
critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one …
critical for skin homeostasis. Previous studies have shown that the barrier dysfunction is one …
[HTML][HTML] Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation
Inflammation of the esophageal epithelium is a hallmark of eosinophilic esophagitis (EoE),
an emerging chronic allergic disease. Herein, we probed human esophageal epithelial cells …
an emerging chronic allergic disease. Herein, we probed human esophageal epithelial cells …
The microbiome and food allergy
The gut-associated lymphoid tissue (GALT) faces a considerable challenge. It encounters
antigens derived from an estimated 1014 commensal microbes and greater than 30 kg of …
antigens derived from an estimated 1014 commensal microbes and greater than 30 kg of …
Pathophysiology of non-IgE-mediated food allergy
S Zhang, S Sicherer, MC Berin… - ImmunoTargets and …, 2021 - Taylor & Francis
Non-IgE-mediated food allergies are a group of disorders characterized by subacute or
chronic inflammatory processes in the gut. Unlike IgE mediated food allergies that may result …
chronic inflammatory processes in the gut. Unlike IgE mediated food allergies that may result …
Butyrate and propionate restore interleukin 13‐compromised esophageal epithelial barrier function
MTA Kleuskens, ML Haasnoot, BM Herpers… - Allergy, 2022 - Wiley Online Library
Abstract Background Eosinophilic esophagitis (EoE) is a food allergen driven disease that is
accompanied by interleukin (IL) 13 overexpression and esophageal barrier dysfunction …
accompanied by interleukin (IL) 13 overexpression and esophageal barrier dysfunction …