Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …

Disease-causing repeat instability is an important and unique form of mutation that is linked
to more than 40 neurological, neurodegenerative and neuromuscular disorders. DNA repeat …

Repetitive DNA motifs are abundant in the genomes of various species and have the
capacity to adopt non-canonical (ie, non-B) DNA structures. Several non-B DNA structures …

The expression of most bacterial genes is controlled at the level of transcription via promoter
control mechanisms that permit a graded response. However, an increasing number of …

More than 20 syndromes among the significant and increasing number of degenerative
diseases of neuronal tissues are known to be associated with diabetes mellitus, increased …

DNA is the molecule chosen by nature to store the information required to build organisms.
These organisms in turn serve to replicate that information. It was initially thought that DNA …

Fragile X syndrome, a common form of inherited mental retardation, is mainly caused by
massive expansion of CGG triplet repeats located in the 5′-untranslated region of the …

In the context of recombinant DNA technology, the development of feasible and high-
yielding plasmid DNA production processes has regained attention as more evidence for its …

Substantial progress has been realized in the past several years in our understanding of the
molecular mechanisms responsible for the expansions and deletions (genetic instabilities) …

Unstable repeats are associated with various types of cancer and have been implicated in
more than 40 neurodegenerative disorders. Trinucleotide repeats are located in non-coding …