Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is
limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Cisplatin is a widely used chemotherapeutic agent used to treat solid tumours, such as
ovarian, head and neck, and testicular germ cell. A known complication of cisplatin …

Histone deacetylases (HDACs) are essential for maintaining homeostasis by catalyzing
histone deacetylation. Aberrant expression of HDACs is associated with various human …

Acute kidney injury (AKI) is a major public health concern associated with high morbidity and
mortality. Despite decades of research, the pathogenesis of AKI remains incompletely …

Aims: Cisplatin, an anticancer drug, always leads to nephrotoxicity by causing mitochondrial
dysfunction. As a major mechanism for cellular self-degradation, autophagy has been …

Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently
reported serious side-effect. However, there are no approved biomarkers that can properly …

Senescence and autophagy play important roles in homeostasis. Cellular senescence and
autophagy commonly cause several degenerative processes, including oxidative stress …

Acute kidney injury (AKI) is a destructive clinical condition induced by multiple insults
including ischemic reperfusion, nephrotoxic drugs and sepsis. It is characterized by a …

Abstract Background Histone deacetylase 6 (HDAC6) has been considered as an important
regulator in the development of inflammatory diseases. However, the mechanism of HDAC6 …

Cisplatin (CP) is a broad-spectrum antineoplastic agent, used to treat many different types of
malignancies due to its high efficacy and low cost. However, its use is largely limited by …