Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …

Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

According to a commonly held view, the obesity pandemic is caused by overconsumption of
modern, highly palatable, energy-dense processed foods, exacerbated by a sedentary …

The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …

Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

The relative insufficiency of insulin secretion and/or insulin action causes diabetes.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …

Lipids play crucial roles in regulating aging and longevity. In the past few decades, a series
of genetic pathways have been discovered to regulate lifespan in model organisms …

Despite intensive research, the causes of the obesity epidemic remain incompletely
understood and conventional calorie-restricted diets continue to lack long-term efficacy …

Insulin resistance is a metabolic disorder affecting multiple tissues and is a precursor event
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …

Twenty-nine years following the breakthrough discovery that a single-gene mutation of daf-2
doubles Caenorhabditis elegans lifespan, it remains unclear where this insulin/IGF-1 …