The steroidal glycoalkaloid α-tomatine (αTM) and its aglycone tomatidine (TD) are abundant
in the skin of unripe green tomato and present in tomato leaves and flowers. They mainly …

Fungi are eukaryotic microorganisms found in nature, which can invade the human body
and cause tissue damage, inflammatory reactions, organ dysfunctions, and diseases. These …

Cholesterol is a critical component of mammalian cell membranes and an allosteric
modulator of G protein-coupled receptors (GPCRs), but divergent views exist on the …

Diosgenin (DSG) is a naturally occurring steroidal saponin with a variety of biological
activities that is also an important precursor for the synthesis of various steroidal drugs. The …

ABSTRACT ATP-binding cassette (ABC) transporters represent one of the largest protein
superfamilies. Functionally diverse, ABC transporters have been implicated in many aspects …

Ergosterol, the major sterol in fungal membranes, is critical for defining membrane fluidity
and regulating cellular processes. Although ergosterol synthesis has been well defined in …

To investigate the underlying resistance mechanisms of Saccharomyces cerevisiae against
Ag-NPs with different particle sizes and coatings, transcriptome sequencing (RNA-seq) …

Treatment of life-threatening cryptococcal meningitis (CM) is highly challenging due to the
limited efficacy of the available antifungal drugs. Antidepressant sertraline (SER) has been …

Isobavachalcone (IBC) is a natural flavonoid with multiple pharmacological properties. This
study aimed to evaluate the efficacy of IBC against planktonic growth and biofilms of …

The antifungal resistance threat posed by Candida auris necessitates bold and innovative
therapeutic options. Farnesol is a quorum-sensing molecule with a potential antifungal …