Role of fibrinolytic enzymes in anti-thrombosis therapy

F Altaf, S Wu, V Kasim - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Thrombosis, a major cause of deaths in this modern era responsible for 31% of all global
deaths reported by WHO in 2017, is due to the aggregation of fibrin in blood vessels which …

Microbial fibrinolytic enzymes as anti-thrombotics: production, characterisation and prodigious biopharmaceutical applications

C Sharma, A Osmolovskiy, R Singh - Pharmaceutics, 2021 - mdpi.com
Cardiac disorders such as acute myocardial infarction, embolism and stroke are primarily
attributed to excessive fibrin accumulation in the blood vessels, usually consequential in …

Purification, physicochemical properties, and statistical optimization of fibrinolytic enzymes especially from fermented foods: a comprehensive review

AMM Ali, SCB Bavisetty - International Journal of Biological …, 2020 - Elsevier
Fibrinolytic enzymes are proteases responsible for cleavage of fibrin mesh in thrombus clots,
which are the primary causative agents in cardiovascular diseases. Developing safe …

Thrombolytic enzymes of microbial origin: a review

D Diwan, Z Usmani, M Sharma, JW Nelson… - International journal of …, 2021 - mdpi.com
Enzyme therapies are attracting significant attention as thrombolytic drugs during the current
scenario owing to their great affinity, specificity, catalytic activity, and stability. Among various …

Production, purification, and functional properties of microbial fibrinolytic enzymes produced by microorganism obtained from soy-based fermented foods …

M Yao, Y Yang, J Fan, C Ma, X Liu… - Critical Reviews in …, 2024 - Taylor & Francis
Abstract According to the World Health Organization, cardiovascular disease (CVD) has
become a major cause of chronic illness around the globe. It has been reported that soy …

[HTML][HTML] Biological safety of Syagrus coronata (Mart.) Becc. Fixed oil: Cytotoxicity, acute oral toxicity, and genotoxicity studies

TG dos Santos Souza, MM da Silva, GS Feitoza… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Syagrus coronata, popularly known as licuri, is a palm
native to caatingas. The fixed oil extract of licuri nuts is used by the population of Northeast …

Partial purification of fibrinolytic and fibrinogenolytic protease from Gliricidia sepium seeds by aqueous two-phase system

AV da Silva, JM do Nascimento, CH Rodrigues… - Biocatalysis and …, 2020 - Elsevier
Fibrinolytic proteases are enzymes that provide a promising alternative to drugs for
thrombolytic therapy, since they degrade fibrin, the major component of blood clots …

Toxicological safety, antioxidant activity and phytochemical characterization of leaf and bark aqueous extracts of Commiphora leptophloeos (Mart.) JB Gillett

LF de Melo Alcântara, PT da Silva… - Journal of Toxicology …, 2023 - Taylor & Francis
This study aimed to characterize the phytochemical profile of bark and leaves aqueous
extract Commiphora leptophloeos, and conduct in vivo and in vitro assays to determine the …

Prospective purification and assay of thrombolytic protease from Bacillus sp. hsfi-10 isolated from sand sea cucumber for antithrombotic agent development

BP Ayanti, SN Ethica, AR Sulisytaningtyas… - … Science (ICBS 2021 …, 2022 - atlantis-press.com
Thrombosis is a cardiovascular disorder due to the formation of a blood clot (thrombus),
which can cause a blockage in a blood vessel. Such abnormality is responsible for more …

Silver nanoprisms as plasmonic enhancers applied in the photodynamic inactivation of Staphylococcus aureus isolated from bubaline mastitis

CH Rodrigues, EAG Araújo, RP Almeida… - Photodiagnosis and …, 2021 - Elsevier
Mastitis is a bacterial infection that affects all lactating mammals, and in dairy cattle, it leads
to a reduction in their milk production and, in worse cases, it may lead to animal death. One …