Retina as a potential biomarker in schizophrenia spectrum disorders: a systematic review and meta-analysis of optical coherence tomography and electroretinography

H Komatsu, G Onoguchi, SM Silverstein, S Jerotic… - Molecular …, 2024 - nature.com
Introduction Abnormal findings on optical coherence tomography (OCT) and
electroretinography (ERG) have been reported in participants with schizophrenia spectrum …

Association between retinal features from multimodal imaging and schizophrenia

SK Wagner, M Cortina-Borja, SM Silverstein… - JAMA …, 2023 - jamanetwork.com
Importance The potential association of schizophrenia with distinct retinal changes is of
clinical interest but has been challenging to investigate because of a lack of sufficiently large …

[HTML][HTML] Optical coherence tomography in schizophrenia spectrum disorders: A systematic review and meta-analysis

W Shew, DJ Zhang, DB Menkes… - … Psychiatry Global Open …, 2024 - Elsevier
Background Inner retinal atrophy has been demonstrated in schizophrenia spectrum
disorder (SSD) using optical coherence tomography (OCT). This systematic review and meta …

Inflammatory subtypes in antipsychotic-naïve first-episode schizophrenia are associated with altered brain morphology and topological organization

D Hoang, Y Xu, O Lutz, D Bannai, V Zeng… - Brain, behavior, and …, 2022 - Elsevier
Background Peripheral inflammation is implicated in schizophrenia, however, not all
individuals demonstrate inflammatory alterations. Recent studies identified inflammatory …

Neuroretinal alterations in schizophrenia and bipolar disorder: an updated meta-analysis

N Sheehan, D Bannai, SM Silverstein… - Schizophrenia …, 2024 - academic.oup.com
Schizophrenia (SZ) and bipolar disorder (BD) are characterized by major symptomatic,
cognitive, and neuroanatomical changes. Recent studies have used optical coherence …

Optical coherence tomography reveals retinal thinning in schizophrenia spectrum disorders

E Boudriot, B Schworm, L Slapakova, K Hanken… - European Archives of …, 2023 - Springer
Abstract Background Schizophrenia spectrum disorders (SSDs) are presumed to be
associated with retinal thinning. However, evidence is lacking as to whether these retinal …

Single-nucleus RNA sequencing of midbrain blood-brain barrier cells in schizophrenia reveals subtle transcriptional changes with overall preservation of cellular …

S Puvogel, A Alsema, L Kracht, MJ Webster… - Molecular …, 2022 - nature.com
The midbrain is an extensively studied brain region in schizophrenia, in view of its reported
dopamine pathophysiology and neuroimmune changes associated with this disease …

[HTML][HTML] Association between polygenic risk for schizophrenia and retinal morphology: A cross-sectional analysis of the United Kingdom Biobank

BA Blose, SM Silverstein, KV Stuart, PA Keane… - Psychiatry …, 2024 - Elsevier
We examined the relationship between genetic risk for schizophrenia (SZ), using polygenic
risk scores (PRSs), and retinal morphological alterations. Retinal structural and vascular …

Deep learning model using retinal vascular images for classifying schizophrenia

A Appaji, V Harish, V Korann, P Devi, A Jacob… - Schizophrenia …, 2022 - Elsevier
Contemporary psychiatric diagnosis still relies on the subjective symptom report of the
patient during a clinical interview by a psychiatrist. Given the significant variability in …

OCT and OCT angiography offer new insights and opportunities in schizophrenia research and treatment

KM Green, JJ Choi, RS Ramchandran… - Frontiers in digital …, 2022 - frontiersin.org
The human retina and retinal imaging technologies continue to increasingly gain the
attention of schizophrenia researchers. With the same embryologic origin as the brain, the …