Background: Bone is a dynamic tissue that continuously undergoes the modeling and
remodeling process to maintain its strength and firmness. Bone remodeling is determined by …

The genus Eriosema (Fabaceae) includes approximately 150 species widely distributed
across tropical and subtropical regions of the world (Africa, Neotropics, Asia and Australia) …

Most patients with senile osteoporosis (SOP) are severely deficient in bone mass, and
treatments using bone resorption inhibitors, such as bisphosphonates, have shown limited …

Ethnopharmacological relevance Psoralea corylifolia L. seeds (P. corylifolia), popularly
known as Buguzhi in traditional Chinese medicine, are often used to treat osteoporosis in …

Treating estrogen-dependent diseases like endometriosis with drugs suppressing local
estrogen activation may be superior to existing endocrine therapies. Steroid sulfatase (STS) …

The chemoselectivity of halo (het) arene sulfonyl halide aminations is studied thoroughly
under parallel synthesis conditions, and the scope and limitations of the method are …

The family of 17β-hydroxysteroid dehydrogenases (17β-HSDs) occupies a prominent place
due to its number of isoforms, which carry out a bidirectional transformation (reduction of a …

The 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) has a key role in estrogen
biosynthesis as it catalyzes the reduction of estrone to the most potent estrogen, estradiol …

Hormone replacement therapy is a viable option to protect bone from postmenopausal
osteoporosis. Systemically elevated estrogen levels, however, are disadvantageous …

Osteoporose ist eine systemische Erkrankung des skelettalen Apparates und äußert sich in
einer Degression der Knochendichte und in der Mikroarchitektur des Knochengewebes. Die …