Human leukocyte antigen (HLA) encoded by the HLA gene is an important modulator for
immune responses and drug hypersensitivity reactions as well. Genetic polymorphisms of …

SCARs are rare and life-threatening hypersensitivity reactions. In general, the increased
duration of hospital stays and the associated cost burden are common issues, and in the …

Adverse drug reactions (ADRs) are a common cause of hospital admissions (up to 19%),
with the majority of cases due to off‐target predictable drug effects (type A reactions) …

Adverse drug reactions are a public health issue that draws widespread attention, especially
for Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) which have high …

Aromatic antiepileptic drugs (AEDs)-induced cutaneous adverse drug reactions (cADRs)
add up to the limited use of the AEDs in the treatment and prevention of seizures. Human …

Aggregated risk of carbamazepine (CBZ)‐induced cutaneous adverse drug reactions
(cADRs) with different HLA variants are unclear and limited in terms of the power of studies …

A case-control study was conducted to investigate the association of HLA-A alleles, HLA-B
alleles including HLA-B* 15: 02 and HLA-B75 serotype with carbamazepine-induced …

Epilepsy treatment is challenging due to heterogeneous syndromes, different seizure types
and higher inter-individual variability. Identification of genetic variants predicting drug …

Immune‐mediated type IV adverse drug reactions are idiosyncratic in nature, generally not
related to the primary or secondary pharmacology of the drug. Due to their complex nature …

Purpose Phenytoin (PHT) is a common causative drug for severe cutaneous adverse drug
reactions (SCARs) in children. SCARs, including drug reaction with eosinophilia and …