Clinical translation of long-acting drug delivery formulations
Most pharmaceuticals are given using short-acting formulations that require frequent
administration, which can negatively affect patient compliance and increase failure risks …
administration, which can negatively affect patient compliance and increase failure risks …
[HTML][HTML] Integrating plant molecular farming and materials research for next-generation vaccines
YH Chung, D Church, EC Koellhoffer, E Osota… - Nature Reviews …, 2022 - nature.com
Biologics—medications derived from a biological source—are increasingly used as
pharmaceuticals, for example, as vaccines. Biologics are usually produced in bacterial …
pharmaceuticals, for example, as vaccines. Biologics are usually produced in bacterial …
Materials for oral delivery of proteins and peptides
TD Brown, KA Whitehead, S Mitragotri - Nature Reviews Materials, 2020 - nature.com
Throughout history, oral administration has been regarded as the most convenient mode of
drug delivery, as it requires minimal expertise and invasiveness. Although oral delivery …
drug delivery, as it requires minimal expertise and invasiveness. Although oral delivery …
[HTML][HTML] Recent advances in the formulation of PLGA microparticles for controlled drug delivery
Polymeric microparticles (MPs) are recognized as very popular carriers to increase the
bioavailability and bio-distribution of both lipophilic and hydrophilic drugs. Among different …
bioavailability and bio-distribution of both lipophilic and hydrophilic drugs. Among different …
[HTML][HTML] PLGA/PLA-based long-acting injectable depot microspheres in clinical use: production and characterization overview for protein/peptide delivery
A Butreddy, RP Gaddam, N Kommineni… - International journal of …, 2021 - mdpi.com
Over the past few decades, long acting injectable (LAI) depots of polylactide-co-glycolide
(PLGA) or polylactic acid (PLA) based microspheres have been developed for controlled …
(PLGA) or polylactic acid (PLA) based microspheres have been developed for controlled …
Current state and challenges in developing oral vaccines
While vaccination remains the most cost effective strategy for disease prevention,
communicable diseases persist as the second leading cause of death worldwide. There is a …
communicable diseases persist as the second leading cause of death worldwide. There is a …
PLGA-based nanoparticles: an overview of biomedical applications
Poly (lactic-co-glycolic acid)(PLGA) is one of the most successfully developed
biodegradable polymers. Among the different polymers developed to formulate polymeric …
biodegradable polymers. Among the different polymers developed to formulate polymeric …
[HTML][HTML] Hydrogel-enabled, local administration and combinatorial delivery of immunotherapies for cancer treatment
Throughout the last decade, interventions to engineer the immune system called
immunotherapy have revolutionized the fields of oncology and autoimmune disease …
immunotherapy have revolutionized the fields of oncology and autoimmune disease …
Advanced materials and processing for drug delivery: the past and the future
Design and synthesis of efficient drug delivery systems are of vital importance for medicine
and healthcare. Materials innovation and nanotechnology have synergistically fueled the …
and healthcare. Materials innovation and nanotechnology have synergistically fueled the …
An overview of clinical and commercial impact of drug delivery systems
AC Anselmo, S Mitragotri - Journal of Controlled Release, 2014 - Elsevier
Drug delivery systems are widely researched and developed to improve the delivery of
pharmaceutical compounds and molecules. The last few decades have seen a marked …
pharmaceutical compounds and molecules. The last few decades have seen a marked …