Clinical translation of long-acting drug delivery formulations

W Li, J Tang, D Lee, TR Tice… - Nature Reviews …, 2022 - nature.com
Most pharmaceuticals are given using short-acting formulations that require frequent
administration, which can negatively affect patient compliance and increase failure risks …

[HTML][HTML] Integrating plant molecular farming and materials research for next-generation vaccines

YH Chung, D Church, EC Koellhoffer, E Osota… - Nature Reviews …, 2022 - nature.com
Biologics—medications derived from a biological source—are increasingly used as
pharmaceuticals, for example, as vaccines. Biologics are usually produced in bacterial …

Materials for oral delivery of proteins and peptides

TD Brown, KA Whitehead, S Mitragotri - Nature Reviews Materials, 2020 - nature.com
Throughout history, oral administration has been regarded as the most convenient mode of
drug delivery, as it requires minimal expertise and invasiveness. Although oral delivery …

[HTML][HTML] Recent advances in the formulation of PLGA microparticles for controlled drug delivery

E Lagreca, V Onesto, C Di Natale, S La Manna… - Progress in …, 2020 - Springer
Polymeric microparticles (MPs) are recognized as very popular carriers to increase the
bioavailability and bio-distribution of both lipophilic and hydrophilic drugs. Among different …

[HTML][HTML] PLGA/PLA-based long-acting injectable depot microspheres in clinical use: production and characterization overview for protein/peptide delivery

A Butreddy, RP Gaddam, N Kommineni… - International journal of …, 2021 - mdpi.com
Over the past few decades, long acting injectable (LAI) depots of polylactide-co-glycolide
(PLGA) or polylactic acid (PLA) based microspheres have been developed for controlled …

Current state and challenges in developing oral vaccines

JEV Ramirez, LA Sharpe, NA Peppas - Advanced drug delivery reviews, 2017 - Elsevier
While vaccination remains the most cost effective strategy for disease prevention,
communicable diseases persist as the second leading cause of death worldwide. There is a …

PLGA-based nanoparticles: an overview of biomedical applications

F Danhier, E Ansorena, JM Silva, R Coco… - Journal of controlled …, 2012 - Elsevier
Poly (lactic-co-glycolic acid)(PLGA) is one of the most successfully developed
biodegradable polymers. Among the different polymers developed to formulate polymeric …

[HTML][HTML] Hydrogel-enabled, local administration and combinatorial delivery of immunotherapies for cancer treatment

A Erfani, AE Diaz, PS Doyle - Materials Today, 2023 - Elsevier
Throughout the last decade, interventions to engineer the immune system called
immunotherapy have revolutionized the fields of oncology and autoimmune disease …

Advanced materials and processing for drug delivery: the past and the future

Y Zhang, HF Chan, KW Leong - Advanced drug delivery reviews, 2013 - Elsevier
Design and synthesis of efficient drug delivery systems are of vital importance for medicine
and healthcare. Materials innovation and nanotechnology have synergistically fueled the …

An overview of clinical and commercial impact of drug delivery systems

AC Anselmo, S Mitragotri - Journal of Controlled Release, 2014 - Elsevier
Drug delivery systems are widely researched and developed to improve the delivery of
pharmaceutical compounds and molecules. The last few decades have seen a marked …