Genetic influences on the developing young brain and risk for neuropsychiatric disorders
Imaging genetics provides an opportunity to discern associations between genetic variants
and brain imaging phenotypes. Historically, the field has focused on adults and adolescents; …
and brain imaging phenotypes. Historically, the field has focused on adults and adolescents; …
Unraveling the Link between Olfactory Deficits and Neuropsychiatric Disorders
Smell loss has caught public attention during the recent COVID-19 pandemic. Research on
olfactory function in health and disease gains new momentum. Smell deficits have long …
olfactory function in health and disease gains new momentum. Smell deficits have long …
Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance
SC Page, SR Sripathy, F Farinelli… - Proceedings of the …, 2022 - National Acad Sciences
Neurons derived from human induced pluripotent stem cells (hiPSCs) have been used to
model basic cellular aspects of neuropsychiatric disorders, but the relationship between the …
model basic cellular aspects of neuropsychiatric disorders, but the relationship between the …
The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorder
Schizophrenia (SZ) and bipolar disorder (BP) are highly heritable major psychiatric
disorders that share a substantial portion of genetic risk as well as their clinical …
disorders that share a substantial portion of genetic risk as well as their clinical …
[HTML][HTML] Microglial WNT5A supports dendritic spines maturation and neuronal firing
There is increasing evidence showing that microglia play a critical role in mediating synapse
formation and spine growth, although the molecular mechanism remains elusive. Here, we …
formation and spine growth, although the molecular mechanism remains elusive. Here, we …
Convergent genomic and pharmacological evidence of PI3K/GSK3 signaling alterations in neurons from schizophrenia patients
Human-induced pluripotent stem cells (hiPSCs) allow for the establishment of brain cellular
models of psychiatric disorders that account for a patient's genetic background. Here, we …
models of psychiatric disorders that account for a patient's genetic background. Here, we …
Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitors
Gene regulatory effects have been difficult to detect at many non-coding loci associated with
brain-related traits, likely because some genetic variants have distinct functions in specific …
brain-related traits, likely because some genetic variants have distinct functions in specific …
Androgen effects on neural plasticity
N Kuwahara, K Nicholson, L Isaacs… - … : Clinical Research and …, 2021 - liebertpub.com
Androgens are synthesized in the brain, gonads, and adrenal glands, in both sexes, exerting
physiologically important effects on the structure and function of the central nervous system …
physiologically important effects on the structure and function of the central nervous system …
[HTML][HTML] The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases
L Cristiano - Genes & Diseases, 2022 - Elsevier
The eukaryotic translation elongation factors (EEFs), ie EEF1A1, EEF1A2, EEF1B2, EEF1D,
EEF1G, EEF1E1 and EEF2, are coding-genes that play a central role in the elongation step …
EEF1G, EEF1E1 and EEF2, are coding-genes that play a central role in the elongation step …
Cultured mesenchymal cells from nasal turbinate as a cellular model of the neurodevelopmental component of schizophrenia etiology
VSK Tung, F Mathews, M Boruk, G Suppa… - International journal of …, 2023 - mdpi.com
The study of neurodevelopmental molecular mechanisms in schizophrenia requires the
development of adequate biological models such as patient-derived cells and their …
development of adequate biological models such as patient-derived cells and their …