Phylogeny to function: PE/PPE protein evolution and impact on Mycobacterium tuberculosis pathogenicity

S Fishbein, N Van Wyk, RM Warren… - Molecular …, 2015 - Wiley Online Library
The pe/ppe genes represent one of the most intriguing aspects of the M ycobacterium
tuberculosis genome. These genes are especially abundant in pathogenic mycobacteria …

Methodological and clinical aspects of the molecular epidemiology of Mycobacterium tuberculosis and other mycobacteria

T Jagielski, A Minias, J van Ingen… - Clinical microbiology …, 2016 - Am Soc Microbiol
Molecular typing has revolutionized epidemiological studies of infectious diseases,
including those of a mycobacterial etiology. With the advent of fingerprinting techniques …

The shared antibiotic resistome of soil bacteria and human pathogens

KJ Forsberg, A Reyes, B Wang, EM Selleck… - science, 2012 - science.org
Soil microbiota represent one of the ancient evolutionary origins of antibiotic resistance and
have been proposed as a reservoir of resistance genes available for exchange with clinical …

[HTML][HTML] Targeted IS-element sequencing uncovers transposition dynamics during selective pressure in enterococci

JM Kirsch, S Ely, ME Stellfox, K Hullahalli… - PLoS …, 2023 - journals.plos.org
Insertion sequences (IS) are simple transposons implicated in the genome evolution of
diverse pathogenic bacterial species. Enterococci have emerged as important human …

[HTML][HTML] New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages

J Gonzalo-Asensio, I Pérez, N Aguiló, S Uranga… - PLoS …, 2018 - journals.plos.org
The insertion Sequence IS 6110, only present in the pathogens of the Mycobacterium
tuberculosis Complex (MTBC), has been the gold-standard epidemiological marker for TB …

Global adaptation to a lipid environment triggers the dormancy-related phenotype of Mycobacterium tuberculosis

JG Rodríguez, AC Hernández, C Helguera-Repetto… - MBio, 2014 - Am Soc Microbiol
Strong evidence supports the idea that fatty acids rather than carbohydrates are the main
energy source of Mycobacterium tuberculosis during infection and latency. Despite that …

[HTML][HTML] Functional genetic variation in pe/ppe genes contributes to diversity in Mycobacterium tuberculosis lineages and potential interactions with the human host

PJ Gómez-González, AD Grabowska… - Frontiers in …, 2023 - frontiersin.org
Introduction Around 10% of the coding potential of Mycobacterium tuberculosis is constituted
by two poorly understood gene families, the pe and ppe loci, thought to be involved in host …

[HTML][HTML] Analysis of IS6110 insertion sites provide a glimpse into genome evolution of Mycobacterium tuberculosis

T Roychowdhury, S Mandal, A Bhattacharya - Scientific reports, 2015 - nature.com
Insertion sequence (IS) 6110 is found at multiple sites in the Mycobacterium tuberculosis
genome and displays a high degree of polymorphism with respect to copy number and …

[HTML][HTML] Mapping IS6110 in high-copy number Mycobacterium tuberculosis strains shows specific insertion points in the Beijing genotype

H Alonso, S Samper, C Martín, I Otal - BMC genomics, 2013 - Springer
Abstract Background Mycobacterium tuberculosis Beijing strains are characterized by a
large number of IS 6110 copies, suggesting the potential implication of this element in the …

[HTML][HTML] IS6110 Copy Number in Multi-Host Mycobacterium bovis Strains Circulating in Bovine Tuberculosis Endemic French Regions

C Charles, C Conde, F Biet, ML Boschiroli… - Frontiers in …, 2022 - frontiersin.org
IS 6110 is an insertion sequence found in the Mycobacterium tuberculosis complex, to which
Mycobacterium bovis belongs, which can play a role in genome plasticity and in bacterial …