[HTML][HTML] Recent progress in Mg-based alloys as a novel bioabsorbable biomaterials for orthopedic applications

F Xing, S Li, D Yin, J Xie, PM Rommens, Z Xiang… - Journal of Magnesium …, 2022 - Elsevier
Traditional orthopedic metal implants, such as titanium (Ti), Ti alloys, and cobalt-chromium
(Co-Cr) alloys, cannot be degraded in vivo. Fracture patients is must always suffer a second …

rs1990622 variant associates with Alzheimer's disease and regulates TMEM106B expression in human brain tissues

Y Hu, J Sun, Y Zhang, H Zhang, S Gao, T Wang, Z Han… - BMC medicine, 2021 - Springer
Background It has been well established that the TMEM106B gene rs1990622 variant was a
frontotemporal dementia (FTD) risk factor. Until recently, growing evidence highlights the …

[HTML][HTML] Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis

V Niemsiri, SB Rosenthal, CM Nievergelt… - Molecular …, 2024 - nature.com
Lithium (Li) is one of the most effective drugs for treating bipolar disorder (BD), however,
there is presently no way to predict response to guide treatment. The aim of this study is to …

Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids

JR Osete, IA Akkouh, O Ievglevskyi… - Molecular …, 2023 - nature.com
Lithium (Li) is recommended for long-term treatment of bipolar disorder (BD). However, its
mechanism of action is still poorly understood. Induced pluripotent stem cell (iPSC)-derived …

Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders

JR Osete, IA Akkouh, DR de Assis, A Szabo… - Molecular …, 2021 - nature.com
Abstract Lithium (Li), valproate (VPA) and lamotrigine (LTG) are commonly used to treat
bipolar disorder (BD). While their clinical efficacy is well established, the mechanisms of …

Chronic Lithium Treatment affects anxious behaviors and theExpression of serotonergic genes in Midbrain Raphe nuclei of defeated male mice

DA Smagin, IL Kovalenko, AG Galyamina… - Biomedicines, 2021 - mdpi.com
There is experimental evidence that chronic social defeat stress is accompanied by the
development of an anxiety, development of a depression-like state, and downregulation of …

A DNA methylation signature discriminates between excellent and non-response to lithium in patients with bipolar disorder type 1

C Marie-Claire, FX Lejeune, E Mundwiller, D Ulveling… - Scientific reports, 2020 - nature.com
Lithium (Li) is the cornerstone maintenance treatment for bipolar disorders (BD), but
response rates are highly variable. To date, no clinical or biological marker is available to …

Effects of psychotropic drugs on ribosomal genes and protein synthesis

ZSJ Liu, TTT Truong, CC Bortolasci, B Spolding… - International Journal of …, 2022 - mdpi.com
Altered protein synthesis has been implicated in the pathophysiology of several
neuropsychiatric disorders, particularly schizophrenia. Ribosomes are the machinery …

Differential expression of gene co-expression networks related to the mTOR signaling pathway in bipolar disorder

SW Park, MK Seo, MJ Webster, JG Lee… - Translational Psychiatry, 2022 - nature.com
Bipolar disorder (BPD) is a severe mental illness characterized by episodes of depression
and mania. To investigate the molecular mechanisms underlying the pathophysiology of …

Effects of anti‐tau immunotherapy on reactive microgliosis, cerebral endotheliopathy, and cognitive function in an experimental model of cerebral malaria

OB Akide Ndunge, HJ Shikani, M Dai… - Journal of …, 2023 - Wiley Online Library
Cerebral malaria (CM), a potentially fatal encephalopathy caused primarily by infection with
Plasmodium falciparum, results in long‐term adverse neuro‐psychiatric sequelae. Neural …