Idiosyncratic toxicity: a convergence of risk factors
RG Ulrich - Annu. Rev. Med., 2007 - annualreviews.org
The therapeutic margin for any drug is based on both toxicity and efficacy. Generally, toxicity
is dose-dependent and is driven either by the therapeutic target or by an untoward target …
is dose-dependent and is driven either by the therapeutic target or by an untoward target …
European AIDS Clinical Society (EACS) guidelines on the prevention and management of metabolic diseases in HIV*
JD Lundgren, M Battegay, G Behrens, S De Wit… - HIV …, 2008 - Wiley Online Library
Background Metabolic diseases are frequently observed in HIV‐infected persons and, as
the risk of contracting these diseases is age‐related, their prevalence will increase in the …
the risk of contracting these diseases is age‐related, their prevalence will increase in the …
Effects of a nucleoside reverse transcriptase inhibitor, stavudine, on glucose disposal and mitochondrial function in muscle of healthy adults
A Fleischman, S Johnsen… - American journal …, 2007 - journals.physiology.org
Mitochondrial dysfunction may contribute to the development of insulin resistance and type 2
diabetes. Nucleoside reverse transcriptase inhibitors (NRTIs), specifically stavudine, are …
diabetes. Nucleoside reverse transcriptase inhibitors (NRTIs), specifically stavudine, are …
[PDF][PDF] Oxidative stress associated to disease progression and toxicity during antiretroviral therapy in human immunodeficiency virus infection
LG del Valle, RG Hernández, JP Ávila - J Virol Microbiol, 2013 - pdfs.semanticscholar.org
Oxidative stress condition arises during imbalance between oxidants and antioxidants of
diverse origin damaging both structure and function of tissues. Oxidative stress has been …
diverse origin damaging both structure and function of tissues. Oxidative stress has been …
Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine
G Song, E Napoli, S Wong, R Hagerman, S Liu… - Molecular …, 2016 - Springer
A 55–200 expansion of the CGG nucleotide repeat in the 5′-UTR of the fragile X mental
retardation 1 gene (FMR1) is the hallmark of the triplet nucleotide disease known as the …
retardation 1 gene (FMR1) is the hallmark of the triplet nucleotide disease known as the …
Human immunodeficiency virus (HIV)-1 viral protein R suppresses transcriptional activity of peroxisome proliferator-activated receptor γ and inhibits adipocyte …
S Shrivastav, T Kino, T Cunningham… - Molecular …, 2008 - academic.oup.com
HIV-1-infected patients may develop lipodystrophy and insulin resistance. We investigated
the effect of the HIV-1 accessory protein viral protein R (Vpr) on the activity of the …
the effect of the HIV-1 accessory protein viral protein R (Vpr) on the activity of the …
Altered Bioenergetics in Primary Dermal Fibroblasts from Adult Carriers of the FMR1 Premutation Before the Onset of the Neurodegenerative Disease Fragile X …
E Napoli, G Song, S Wong, R Hagerman, C Giulivi - The Cerebellum, 2016 - Springer
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late onset neurodegenerative
disorder, characterized by tremors, ataxia, impaired coordination, and cognitive decline …
disorder, characterized by tremors, ataxia, impaired coordination, and cognitive decline …
Depletion of mitochondrial DNA in leukocytes of patients with poly-Q diseases
Polyglutamine (poly-Q) diseases are late-onset neurodegenerative disorders arising from
the expansion of an unstable CAG repeat in the affected gene, which is translated to a tract …
the expansion of an unstable CAG repeat in the affected gene, which is translated to a tract …
Drugs and dilated cardiomyopathies: a case/noncase study in the French PharmacoVigilance Database
G Montastruc, S Favreliere, A Sommet… - British journal of …, 2010 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Dilated cardiomyopathy is a frequent
disease, responsible for 40–50% of cases of heart failure.• Several aetiologies have been …
disease, responsible for 40–50% of cases of heart failure.• Several aetiologies have been …
Improvement of mitochondrial toxicity in patients receiving a nucleoside reverse-transcriptase inhibitor-sparing strategy: results from the Multicenter Study with …
Background. Nucleoside reverse-transcriptase inhibitor (NRTI)-related mitochondrial toxicity
has been suggested as a key factor in the induction of antiretroviral-related lipoatrophy. This …
has been suggested as a key factor in the induction of antiretroviral-related lipoatrophy. This …