[HTML][HTML] Protein kinase CK2: a potential therapeutic target for diverse human diseases
CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …
substrates, controls several signaling pathways, and is implicated in a plethora of human …
[HTML][HTML] Exploring vitamin D metabolism and function in cancer
Vitamin D, traditionally known as an essential nutrient, is a precursor of a potent steroid
hormone that regulates a broad spectrum of physiological processes. In addition to its …
hormone that regulates a broad spectrum of physiological processes. In addition to its …
[HTML][HTML] Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors
Medicinal chemistry has discovered thousands of potent protein and lipid kinase inhibitors.
These may be developed into therapeutic drugs or chemical probes to study kinase biology …
These may be developed into therapeutic drugs or chemical probes to study kinase biology …
[HTML][HTML] Hypoxia and selective autophagy in cancer development and therapy
Low oxygen availability, a condition known as hypoxia, is a common feature of various
pathologies including stroke, ischemic heart disease, and cancer. Hypoxia adaptation …
pathologies including stroke, ischemic heart disease, and cancer. Hypoxia adaptation …
Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for the …
F Pierre, PC Chua, SE O'Brien… - Journal of medicinal …, 2011 - ACS Publications
Herein we chronicle the discovery of CX-4945 (25n), a first-in-class, orally bioavailable ATP-
competitive inhibitor of protein kinase CK2 in clinical trials for cancer. CK2 has long been …
competitive inhibitor of protein kinase CK2 in clinical trials for cancer. CK2 has long been …
[HTML][HTML] Role of protein kinase CK2 in antitumor drug resistance
Drug resistance represents the major reason of pharmacological treatment failure. It is
supported by a broad spectrum of mechanisms, whose molecular bases have been …
supported by a broad spectrum of mechanisms, whose molecular bases have been …
[HTML][HTML] Role of CK2 inhibitor CX-4945 in anti-cancer combination therapy–potential clinical relevance
Background Protein kinase CK2 inhibition has long been considered as an attractive anti-
cancer strategy based on the following considerations: CK2 is a pro-survival kinase, it is …
cancer strategy based on the following considerations: CK2 is a pro-survival kinase, it is …
[HTML][HTML] Mining CK2 in cancer
CE Ortega, Y Seidner, I Dominguez - Plos one, 2014 - journals.plos.org
Cancer is a leading cause of death worldwide. Cancer cells proliferate uncontrollably and,
many cases, spread to other parts of the body. A protein historically involved in cancer is …
many cases, spread to other parts of the body. A protein historically involved in cancer is …
[HTML][HTML] Targeting CK2 in cancer: a valuable strategy or a waste of time?
CK2 is a protein kinase involved in several human diseases (ranging from neurological and
cardiovascular diseases to autoimmune disorders, diabetes, and infections, including …
cardiovascular diseases to autoimmune disorders, diabetes, and infections, including …
[HTML][HTML] Protein kinase CK2–diverse roles in cancer cell biology and therapeutic promise
JH Trembley, BT Kren, M Afzal, GA Scaria… - Molecular and cellular …, 2023 - Springer
The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …