Acute lymphoblastic leukaemia (ALL) is a haematological malignancy characterized by the
uncontrolled proliferation of immature lymphoid cells. Over past decades, significant …

The current classification of acute myeloid leukemia (AML) relies largely on genomic
alterations. Robust identification of clinically and biologically relevant molecular subtypes …

Programming T cells to distinguish self from non-self is a vital, multi-step process that occurs
in the thymus,,–. Signalling through the pre-T cell receptor (preTCR), a CD3-associated …

Transcription factors (TFs) play a critical role as key mediators of a multitude of
developmental pathways, with highly regulated and tightly organized networks crucial for …

With the introduction of the 5th edition of the WHO classification, the number of genetically
defined entities in myeloid neoplasms and BCP-ALL has increased considerably [1, 2] …

Acute lymphoblastic leukemia (ALL) is the most common cause of cancer-related death in
children. Despite significantly increased chances of cure, especially for high-risk ALL …

The epigenetic landscape plays a critical role in cancer progression, yet its therapeutic
potential remains underexplored. Glucocorticoids are essential components of treatments for …

In contrast to B-cell precursor acute lymphoblastic leukemia (ALL), molecular subgroups are
less well defined in T-lineage ALL. Comprehensive studies on molecular T-ALL subgroups …

The PICALM:: MLLT10 fusion is a rare but recurrent cytogenetic abnormality in acute
leukemia, with limited clinicopathologic and outcome data available. Herein, we analyzed …

The subtypes of hematological malignancies (HM) with minimal molecular profile differences
display an extremely heterogeneous clinical course and a discrepant response to certain …