A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition

W Xu, Z Yang, N Lu - Cell adhesion & migration, 2015 - Taylor & Francis
Tumor metastasis is not only a sign of disease severity but also a major factor causing
treatment failure and cancer-related death. Therefore, studies on the molecular mechanisms …

Medicinal properties of mangosteen (Garcinia mangostana L.): A comprehensive update

B Ovalle-Magallanes, D Eugenio-Pérez… - Food and Chemical …, 2017 - Elsevier
Garcinia mangostana L.(Clusiaceae) is a tropical tree native to Southeast Asia known as
mangosteen which fruits possess a distinctive and pleasant taste that has granted them the …

LAMB3 mediates apoptotic, proliferative, invasive, and metastatic behaviors in pancreatic cancer by regulating the PI3K/Akt signaling pathway

H Zhang, Y Pan, M Cheung, M Cao, C Yu, L Chen… - Cell death & …, 2019 - nature.com
The poor prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) is partially
attributed to the invasive and metastatic behavior of this disease. Laminin subunit beta-3 …

Small molecule inhibitors of epithelial‐mesenchymal transition for the treatment of cancer and fibrosis

YL Feng, DQ Chen, ND Vaziri, Y Guo… - Medicinal research …, 2020 - Wiley Online Library
Tissue fibrosis and cancer both lead to high morbidity and mortality worldwide; thus,
effective therapeutic strategies are urgently needed. Because drug resistance has been …

Polyphenolic phytochemicals in cancer prevention and therapy: bioavailability versus bioefficacy

JM Estrela, S Mena, E Obrador… - Journal of medicinal …, 2017 - ACS Publications
Natural polyphenols are organic chemicals which contain phenol units in their structures.
They show antitumor properties. However, a key problem is their short half-life and low …

Bioactivity and pharmacological properties of α-mangostin from the mangosteen fruit: a review

G Chen, Y Li, W Wang, L Deng - Expert opinion on therapeutic …, 2018 - Taylor & Francis
ABSTRACT Introduction: α-Mangostin (α-MG) is the most representative xanthone isolated
from the pericarp of mangosteen, possessing extensive biological activities and …

[HTML][HTML] Mangosteen for malignancy prevention and intervention: Current evidence, molecular mechanisms, and future perspectives

LS Kalick, HA Khan, E Maung, Y Baez… - Pharmacological …, 2023 - Elsevier
Abstract Mangosteen (Garcinia mangostana L.), also known as the “queen of fruits”, is a
tropical fruit of the Clusiacea family. While native to Southeast Asian countries, such as …

lncRNA DANCR promotes the migration an invasion and of trophoblast cells through microRNA-214-5p in preeclampsia

Q Zhang, Z Wang, X Cheng, H Wu - Bioengineered, 2021 - Taylor & Francis
Studies have shown that lncRNA DANCR is down-regulated in placental tissues of patients
with preeclampsia (PE). The aim of this study was to explore the effect of lncRNA DANCR on …

The purple mangosteen (Garcinia mangostana): Defining the anticancer potential of selected xanthones

MC Nauman, JJ Johnson - Pharmacological research, 2022 - Elsevier
The purple mangosteen (Garcinia mangostana) is a popular Southeast Asian fruit that has
been used traditionally for its health promoting benefits for years. Unique to the mangosteen …

Anticarcinogenic effects of α-mangostin: a review

K Zhang, Q Gu, K Yang, X Ming, J Wang - Planta medica, 2017 - thieme-connect.com
Cancer chemoprevention is a promising strategy taken to block, reverse, or retard
carcinogenesis. α-Mangostin, a natural xanthone isolated from the pericarps of mangosteen …