Gene therapy utilizes nucleic acid drugs to treat diseases, encompassing gene
supplementation, gene replacement, gene silencing, and gene editing. It represents a …

Neonatal porcine islets (NPIs) are a source of islets for xenotransplantation. In the pig, the
pancreatic lobes remain separate, thus, when optimizing NPI isolation, the pancreatic lobes …

Xenotransplantation of porcine islets holds great promise as a cure for type 1 diabetes, but
several immunological and practical hurdles remain to be overcome before this procedure …

Type 1 diabetes mellitus (T1DM) is characterized by absolute insulin deficiency primarily
due to autoimmune destruction of pancreatic β‐cells. The prevailing treatment for T1DM …

Insulin replacement therapy is the mainstay treatment option for type 1 diabetes; however,
when this fails to adequately maintain glucose homeostasis, islet transplantation can …

Younger pigs only require the mothers to be held for long term, whereas the isolation of
adult pig islets requires significant infrastructure and expense as the pigs for islet isolation …