Mass spectrometry (MS) has become one of the key technologies of structural biology. In this
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …

In recent decades, mass spectrometry has moved more than ever before into the front line of
protein-centered research. After being established at the qualitative level, the more …

Vendor-independent software tools for quantification of small molecules and metabolites are
lacking, especially for targeted analysis workflows. Skyline is a freely available, open-source …

Protein-protein interactions are fundamental to the formation of intricate interaction networks
and the assembly of multisubunit protein complexes that represent the functional …

Mitochondrial protein interactions and complexes facilitate mitochondrial function. These
complexes range from simple dimers to the respirasome supercomplex consisting of …

Mass spectrometry (MS) is increasingly being used to probe the structure and dynamics of
proteins and the complexes they form with other macromolecules. There are now several …

Highlights•Cross-linking-mass spectrometry constitutes a chemical method to produce
protein complex structural model constraints.•A wide range of sample types are applicable …

Highlights•Lipoylation is a rare, but highly conserved lysine posttranslational modification.•
Lipoylated metabolic complexes are evolutionarily conserved from bacteria to humans.• …

While modern structural biology technologies have greatly expanded the size and type of
protein complexes that can now be studied, the ability to derive large-scale structural …

For the last century we have relied on model organisms to help understand fundamental
biological processes. Now, with advancements in genome sequencing, assembly, and …