New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD

A Larabi, N Barnich, HTT Nguyen - Autophagy, 2020 - Taylor & Francis
One of the most significant challenges of inflammatory bowel disease (IBD) research is to
understand how alterations in the symbiotic relationship between the genetic composition of …

The role of autophagy in inflammatory bowel disease

BZ Shao, Y Yao, JS Zhai, JH Zhu, JP Li… - Frontiers in Physiology, 2021 - frontiersin.org
Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease, including
ulcerative colitis (UC) and Crohn's disease (CD). The abnormality of inflammatory and …

Human intestinal macrophages are involved in the pathology of both ulcerative colitis and Crohn disease

S Dharmasiri, EM Garrido-Martin… - Inflammatory bowel …, 2021 - academic.oup.com
Background Intestinal macrophages are key immune cells in the maintenance of intestinal
immune homeostasis and have a role in the pathogenesis of inflammatory bowel disease …

Impaired lipophagy induced-microglial lipid droplets accumulation contributes to the buildup of TREM1 in diabetes-associated cognitive impairment

Q Li, Y Zhao, H Guo, Q Li, C Yan, Y Li, S He, N Wang… - Autophagy, 2023 - Taylor & Francis
Neuroinflammation caused by microglial activation and consequent neurological impairment
are prominent features of diabetes-associated cognitive impairment (DACI). Microglial …

Low TREM1 expression in whole blood predicts anti-TNF response in inflammatory bowel disease

B Verstockt, S Verstockt, J Dehairs, V Ballet, H Blevi… - …, 2019 - thelancet.com
Background With the changed therapeutic armamentarium for Crohn's disease (CD) and
ulcerative colitis (UC), biomarkers predicting treatment response are urgently needed. We …

The microglial innate immune receptors TREM-1 and TREM-2 in the anterior cingulate cortex (ACC) drive visceral hypersensitivity and depressive-like behaviors …

K Wu, Y Liu, S Shao, W Song, X Chen, Y Dong… - Brain, Behavior, and …, 2023 - Elsevier
Inflammatory bowel disease (IBD) is a chronic condition with a high recurrence rate. To date,
the clinical treatment of IBD mainly focuses on inflammation and gastrointestinal symptoms …

PET imaging of TREM1 identifies CNS-infiltrating myeloid cells in a mouse model of multiple sclerosis

AM Chaney, HC Cropper, P Jain, E Wilson… - Science translational …, 2023 - science.org
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous
system (CNS) that causes substantial morbidity and diminished quality of life. Evidence …

An orally administered butyrate-releasing xylan derivative reduces inflammation in dextran sulphate sodium-induced murine colitis

Z Zha, Y Lv, H Tang, T Li, Y Miao, J Cheng… - International Journal of …, 2020 - Elsevier
Butyrate has been shown to be effective in ulcerative colitis (UC). However, its oral
administration is rare due to its rancid odour and unpleasant taste. In this study, the effect of …

Regulation of endoplasmic reticulum stress-autophagy: a potential therapeutic target for ulcerative colitis

D Qiao, Z Zhang, Y Zhang, Q Chen, Y Chen… - Frontiers in …, 2021 - frontiersin.org
Ulcerative colitis (UC) is a chronic nonspecific inflammation that mainly affects the mucosa
and submucosa of the rectum and colon. Numerous studies have shown that endoplasmic …

How autophagy, a potential therapeutic target, regulates intestinal inflammation

SL Chen, CM Li, W Li, QS Liu, SY Hu, MY Zhao… - Frontiers in …, 2023 - frontiersin.org
Inflammatory bowel disease (IBD) is a group of disorders that cause chronic inflammation in
the intestines, with the primary types including ulcerative colitis and Crohn's disease. The …