The short-term stress response–Mother nature's mechanism for enhancing protection and performance under conditions of threat, challenge, and opportunity

FS Dhabhar - Frontiers in neuroendocrinology, 2018 - Elsevier
Our group has proposed that in contrast to chronic stress that can have harmful effects, the
short-term (fight-or-flight) stress response (lasting for minutes to hours) is nature's …

The impact of psychosocial stress and stress management on immune responses in patients with cancer

MH Antoni, FS Dhabhar - Cancer, 2019 - Wiley Online Library
The range of psychosocial stress factors/processes (eg, chronic stress, distress states,
coping, social adversity) were reviewed as they relate to immune variables in cancer along …

Effects of stress on immune function: the good, the bad, and the beautiful

FS Dhabhar - Immunologic research, 2014 - Springer
Although the concept of stress has earned a bad reputation, it is important to recognize that
the adaptive purpose of a physiological stress response is to promote survival during fight or …

Stress-induced redistribution of immune cells—From barracks to boulevards to battlefields: A tale of three hormones–Curt Richter Award Winner

FS Dhabhar, WB Malarkey, E Neri… - Psychoneuroendocrinology, 2012 - Elsevier
BACKGROUND: The surveillance and effector functions of the immune system are critically
dependent on the appropriate distribution of immune cells in the body. An acute or short …

Stress, adaptation, and disease: Allostasis and allostatic load

BS McEwen - Annals of the New York academy of sciences, 1998 - Wiley Online Library
Adaptation in the face of potentially stressful challenges involves activation of neural,
neuroendocrine and neuroendocrine‐immune mechanisms. This has been called …

Biological sensitivity to context: I. An evolutionary–developmental theory of the origins and functions of stress reactivity

WT Boyce, BJ Ellis - Development and psychopathology, 2005 - cambridge.org
Biological reactivity to psychological stressors comprises a complex, integrated, and highly
conserved repertoire of central neural and peripheral neuroendocrine responses designed …

Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations

MJ Meaney - Annual review of neuroscience, 2001 - annualreviews.org
▪ Abstract Naturally occurring variations in maternal care alter the expression of genes that
regulate behavioral and endocrine responses to stress, as well as hippocampal synaptic …

Enhancing versus suppressive effects of stress on immune function: implications for immunoprotection and immunopathology

FS Dhabhar - Neuroimmunomodulation, 2009 - karger.com
Stress is known to suppress immune function and increase susceptibility to infections and
cancer. Paradoxically, stress is also known to exacerbate asthma, and allergic, autoimmune …

The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders

C Heim, U Ehlert, DH Hellhammer - Psychoneuroendocrinology, 2000 - Elsevier
Representing a challenge for current concepts of stress research, a number of studies have
now provided convincing evidence that the adrenal gland is hypoactive in some stress …

Acute stress enhances while chronic stress suppresses cell-mediated immunityin vivo: A potential role for leukocyte trafficking

FS Dhabhar, BS Mcewen - Brain, behavior, and immunity, 1997 - Elsevier
Delayed type hypersensitivity (DTH) reactions are antigen-specific, cell-mediated immune
responses which, depending on the antigen involved, mediate beneficial (resistance to …