Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …

Enabled by new approaches for rapid identification and selection of human monoclonal
antibodies, atomic-level structural information for viral surface proteins, and capacity for …

Background A recombinant, replication-competent vesicular stomatitis virus-based vaccine
expressing a surface glycoprotein of Zaire Ebolavirus (rVSV-ZEBOV) is a promising Ebola …

Importance Developing effective vaccines against Ebola virus is a global priority. Objective
To evaluate an adenovirus type 26 vector vaccine encoding Ebola glycoprotein (Ad26 …

Background The unprecedented 2014 epidemic of Ebola virus disease (EVD) prompted an
international response to accelerate the availability of a preventive vaccine. A replication …

Ebolavirus disease causes high mortality, and the current outbreak has spread unabated
through West Africa. Human adenovirus type 5 vectors (rAd5) encoding ebolavirus …

Background The West African outbreak of Ebola virus disease that peaked in 2014 has
caused more than 11,000 deaths. The development of an effective Ebola vaccine is a priority …

Adenoviral vectors are a safe and potently immunogenic vaccine delivery platform. Non-
replicating Ad vectors possess several attributes which make them attractive vaccines for …

Filovirus infections can cause a severe and often fatal disease in humans and nonhuman
primates, including great apes. Here, three anti-Ebola virus mouse/human chimeric mAbs …

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