Identification of potential novel therapeutic drug target against Elizabethkingia anophelis by integrative pan and subtractive genomic analysis: An in silico approach
P Sarker, A Mitro, H Hoque, MN Hasan… - Computers in Biology …, 2023 - Elsevier
Elizabethkingia anophelis is a human pathogen responsible for severe nosocomial
infections in neonates and immunocompromised patients. The significantly higher mortality …
infections in neonates and immunocompromised patients. The significantly higher mortality …
In silico structure-based designers of therapeutic targets for diabetes mellitus or obesity: A protocol for systematic review
AFT Gomes, WF de Medeiros, GS de Oliveira… - PLoS …, 2022 - journals.plos.org
Obesity is a significant risk factor for several chronic non-communicable diseases, being
closely related to Diabetes Mellitus. Computer modeling techniques favor the understanding …
closely related to Diabetes Mellitus. Computer modeling techniques favor the understanding …
Pangenome Analysis of Mycobacterium tuberculosis Reveals Core-Drug Targets and Screening of Promising Lead Compounds for Drug Discovery
Tuberculosis, caused by Mycobacterium tuberculosis (M. tuberculosis), is one of the leading
causes of human deaths globally according to the WHO TB 2019 report. The continuous rise …
causes of human deaths globally according to the WHO TB 2019 report. The continuous rise …
Exploring optimal drug targets through subtractive proteomics analysis and pangenomic insights for tailored drug design in tuberculosis
Tuberculosis (TB), caused by Mycobacterium tuberculosis, ranks among the top causes of
global human mortality, as reported by the World Health Organization's 2022 TB report. The …
global human mortality, as reported by the World Health Organization's 2022 TB report. The …
Discovery of novel DprE1 inhibitors via computational bioactivity fingerprints and structure-based virtual screening
X Hu, L Yang, X Chai, Y Lei, MS Alam, L Liu… - Acta Pharmacologica …, 2022 - nature.com
Decaprenylphosphoryl-β-D-ribose oxidase (DprE1) plays important roles in the biosynthesis
of mycobacterium cell wall. DprE1 inhibitors have shown great potentials in the development …
of mycobacterium cell wall. DprE1 inhibitors have shown great potentials in the development …
Identification of novel scaffold using ligand and structure based approach targeting shikimate kinase
MBR Reddy, SK Krishnasamy, MK Kathiravan - Bioorganic Chemistry, 2020 - Elsevier
Tuberculosis (TB) remains a major global health problem. It causes ill-health among millions
of people each year and rank as the second leading cause of death from an infectious …
of people each year and rank as the second leading cause of death from an infectious …
(R)-(+)-Lasiodiplodin isolated from the endophytic fungus Sordaria tamaensis exhibits potent antimycobacterial and anti-inflammatory activities in vitro and in vivo …
SD Calixto, TLBV Simão, FM de Almeida… - Journal of Pharmacy …, 2022 - academic.oup.com
Objectives This study aimed to evaluate endophytic fungi isolated from Tocoyena bullata
and Humiria balsamifera plant species for their antimycobacterial and anti-inflammatory …
and Humiria balsamifera plant species for their antimycobacterial and anti-inflammatory …
In vitro and in silico evaluations of actinomycin X2and actinomycin D as potent anti-tuberculosis agents
Background Multidrug-resistant tuberculosis (MDR-TB) is one of the world's most
devastating contagious diseases and is caused by the MDR-Mycobacterium tuberculosis …
devastating contagious diseases and is caused by the MDR-Mycobacterium tuberculosis …
In silico Prediction of New Drug Candidates Against the Multidrug-Resistant and Potentially Zoonotic Fish Pathogen Serotype III Streptococcus agalactiae
LM Favero, RT Chideroli, NA Ferrari… - Frontiers in …, 2020 - frontiersin.org
Streptococcus agalactiae is an invasive multi-host pathogen that causes invasive diseases
mainly in newborns, elderly, and individuals with underlying health complications. In fish, S …
mainly in newborns, elderly, and individuals with underlying health complications. In fish, S …
Docking moléculaire des composés à base de sulfonamide en tant qu'inhibiteurs potentiels de l'ACE-2
DR RAMDANI AMIRA - 2022 - dspace.univ-guelma.dz
Résumé L'ACE2 est une protéine clé dans la physiologie du COVID-19, permet au virus
Sars-CoV-2 de pénétrer dans les cellules hôtes où la réplication du virus a lieu. L'inhibition …
Sars-CoV-2 de pénétrer dans les cellules hôtes où la réplication du virus a lieu. L'inhibition …