Better living through understanding the insula: Why subregions can make all the difference

SW Centanni, AC Janes, DL Haggerty, B Atwood… - …, 2021 - Elsevier
Insula function is considered critical for many motivated behaviors, with proposed functions
ranging from attention, behavioral control, emotional regulation, goal-directed and aversion …

It's more than just interoception: The insular cortex involvement in alcohol use disorder

EJ Campbell, AJ Lawrence - Journal of neurochemistry, 2021 - Wiley Online Library
Understanding brain structures and circuits impacted by alcohol use disorder is critical for
improving our future prevention techniques and treatment options. A brain region that has …

Brain network dysfunctions in addiction: a meta-analysis of resting-state functional connectivity

S Tolomeo, R Yu - Translational psychiatry, 2022 - nature.com
Resting-state functional connectivity (rsFC) provides novel insights into variabilities in neural
networks associated with the use of addictive drugs or with addictive behavioral repertoire …

An orbitofrontal cortex–anterior insular cortex circuit gates compulsive cocaine use

Y Chen, G Wang, W Zhang, Y Han, L Zhang, H Xu… - Science …, 2022 - science.org
Compulsive drug use, a cardinal symptom of drug addiction, is characterized by persistent
substance use despite adverse consequences. However, little is known about the neural …

Brain network allostasis after chronic alcohol drinking is characterized by functional dedifferentiation and narrowing

Ú Pérez-Ramírez, VJ López-Madrona… - Journal of …, 2022 - Soc Neuroscience
Alcohol use disorder (AUD) causes complex alterations in the brain that are poorly
understood. The heterogeneity of drinking patterns and the high incidence of comorbid …

Alcohol use and interoception–A narrative review

P Wiśniewski, P Maurage, A Jakubczyk… - Progress in Neuro …, 2021 - Elsevier
Interoception, defined as the ability to perceive and interpret body signals, may play an
important role in alcohol use disorder (AUD). Earlier studies suggested an association …

Similarity and difference in large-scale functional network alternations between behavioral addictions and substance use disorder: a comparative meta-analysis

X Zeng, X Han, D Zheng, P Jiang, Z Yuan - Psychological Medicine, 2024 - cambridge.org
Behavioral addiction (BA) and substance use disorder (SUD) share similarities and
differences in clinical symptoms, cognitive functions, and behavioral attributes. However …

Increased network centrality of the anterior insula in early abstinence from alcohol

C Bordier, G Weil, P Bach, G Scuppa… - Addiction …, 2022 - Wiley Online Library
Abnormal resting‐state functional connectivity, as measured by functional magnetic
resonance imaging (MRI), has been reported in alcohol use disorders (AUD), but findings …

Drinking reduction during cognitive behavioral therapy for alcohol use disorder is associated with a reduction in anterior insula‐bed nucleus of the stria terminalis …

AB Srivastava, J Sanchez‐Peña… - Alcoholism: Clinical …, 2021 - Wiley Online Library
Background Connectivity between the anterior insula (AI) and the bed nucleus of the stria
terminalis (BNST) may play a role in negative emotions that drive compulsive drinking in …

Alcohol use disorder‐associated structural and functional characteristics of the insula

T Manuweera, MA Kisner, E Almira… - Journal of …, 2022 - Wiley Online Library
Based on our current understanding of insular regions, effects of chronic alcohol use on the
insula may affect the integration of sensory‐motor, socio‐emotional, and cognitive function …