[HTML][HTML] Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

MS de Almeida, E Susnik, B Drasler… - Chemical society …, 2021 - pubs.rsc.org
Nanoparticles (NPs) have attracted considerable attention in various fields, such as
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …

Chemical and biophysical signatures of the protein corona in nanomedicine

J Ren, N Andrikopoulos, K Velonia… - Journal of the …, 2022 - ACS Publications
An inconvenient hurdle in the practice of nanomedicine is the protein corona, a spontaneous
collection of biomolecular species by nanoparticles in living systems. The protein corona is …

The effects of protein corona on in vivo fate of nanocarriers

Q Xiao, M Zoulikha, M Qiu, C Teng, C Lin, X Li… - Advanced Drug Delivery …, 2022 - Elsevier
With the emerging advances in utilizing nanocarriers for biomedical applications, a
molecular-level understanding of the in vivo fate of nanocarriers is necessary. After …

The protein corona and its effects on nanoparticle-based drug delivery systems

H Li, Y Wang, Q Tang, D Yin, C Tang, E He, L Zou… - Acta Biomaterialia, 2021 - Elsevier
In most cases, once nanoparticles (NPs) enter the blood, their surface is covered by
biological molecules, especially proteins, forming a so-called protein corona (PC). As a …

[HTML][HTML] Nanoparticle elasticity affects systemic circulation lifetime by modulating adsorption of apolipoprotein AI in corona formation

M Li, X Jin, T Liu, F Fan, F Gao, S Chai… - Nature communications, 2022 - nature.com
Nanoparticle elasticity is crucial in nanoparticles' physiological fate, but how this occurs is
largely unknown. Using core-shell nanoparticles with a same PEGylated lipid bilayer shell …

[HTML][HTML] Overcoming the obstacles of current photodynamic therapy in tumors using nanoparticles

D Lee, S Kwon, S Jang, E Park, Y Lee, H Koo - Bioactive Materials, 2022 - Elsevier
Photodynamic therapy (PDT) has been applied in clinical treatment of tumors for a long time.
However, insufficient supply of pivotal factors including photosensitizer (PS), light, and …

Influence of surface chemistry and morphology of nanoparticles on protein corona formation

R Bilardo, F Traldi, A Vdovchenko… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Nanomaterials offer promising solutions as drug delivery systems and imaging agents in
response to the demand for better therapeutics and diagnostics. However, the limited …

Size-Dependent In Vivo Transport of Nanoparticles: Implications for Delivery, Targeting, and Clearance

M Xu, Y Qi, G Liu, Y Song, X Jiang, B Du - ACS nano, 2023 - ACS Publications
Understanding the in vivo transport of nanoparticles provides guidelines for designing
nanomedicines with higher efficacy and fewer side effects. Among many factors, the size of …

[HTML][HTML] Super-stable cyanine@ albumin fluorophore for enhanced NIR-II bioimaging

L Bai, Z Hu, T Han, Y Wang, J Xu, G Jiang, X Feng… - Theranostics, 2022 - ncbi.nlm.nih.gov
Abstract Near-infrared-II (NIR-II) dyes could be encapsulated by either exogenous or
endogenous albumin to form stable complexes for deep tissue bioimaging. However, we still …

Engineering self-assembling protein nanoparticles for therapeutic delivery

A Olshefsky, C Richardson, SH Pun… - Bioconjugate …, 2022 - ACS Publications
Despite remarkable advances over the past several decades, many therapeutic
nanomaterials fail to overcome major in vivo delivery barriers. Controlling immunogenicity …