Role of human milk bioactives on infants' gut and immune health

LE Carr, MD Virmani, F Rosa, D Munblit… - Frontiers in …, 2021 - frontiersin.org
Exclusive human milk feeding of the newborn is recommended during the first 6 months of
life to promote optimal health outcomes during early life and beyond. Human milk contains a …

[HTML][HTML] Human milk oligosaccharides: Shaping the infant gut microbiota and supporting health

C Walsh, JA Lane, D van Sinderen… - Journal of Functional …, 2020 - Elsevier
Human milk oligosaccharides (HMO) are complex sugars which are found in breast milk at
significant concentrations and with unique structural diversity. These sugars are the fourth …

Human milk oligosaccharide DSLNT and gut microbiome in preterm infants predicts necrotising enterocolitis

AC Masi, ND Embleton, CA Lamb, G Young… - Gut, 2021 - gut.bmj.com
Objective Necrotising enterocolitis (NEC) is a devastating intestinal disease primarily
affecting preterm infants. The underlying mechanisms are poorly understood: mother's own …

Human milk oligosaccharides: 2′-fucosyllactose (2′-FL) and lacto-N-neotetraose (LNnT) in infant formula

Y Vandenplas, B Berger, VP Carnielli, J Ksiazyk… - Nutrients, 2018 - mdpi.com
The authors reviewed the published evidence on the presence of oligosaccharides in
human milk (HMO) and their benefits in in vitro and in vivo studies. The still limited data of …

Functional effects of human milk oligosaccharides (HMOs)

M Dinleyici, J Barbieur, EC Dinleyici, Y Vandenplas - Gut Microbes, 2023 - Taylor & Francis
Human milk oligosaccharides (HMOs) are the third most important solid component in
human milk and act in tandem with other bioactive components. Individual HMO levels and …

Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants

KP Gopalakrishna, BR Macadangdang, MB Rogers… - Nature medicine, 2019 - nature.com
Neonates are protected from colonizing bacteria by antibodies secreted into maternal milk.
Necrotizing enterocolitis (NEC) is a disease of neonatal preterm infants with high morbidity …

Immunological effects of human milk oligosaccharides

V Triantis, L Bode, RJJ Van Neerven - Frontiers in pediatrics, 2018 - frontiersin.org
Human milk oligosaccharides (HMOs) comprise a group of structurally complex,
unconjugated glycans that are highly abundant in human milk. HMOs are minimally digested …

The human milk oligosaccharides 2'-fucosyllactose and 6'-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 …

CP Sodhi, P Wipf, Y Yamaguchi, WB Fulton… - Pediatric …, 2021 - nature.com
Background Necrotizing enterocolitis (NEC) develops through exaggerated toll-like receptor
4 (TLR4) signaling in the intestinal epithelium. Breast milk is rich in non-digestible …

A review of the immunomodulating components of maternal breast milk and protection against necrotizing enterocolitis

LS Nolan, OB Parks, M Good - Nutrients, 2019 - mdpi.com
Breast milk contains immunomodulating components that are beneficial to newborns during
maturation of their immune system. Human breast milk composition is influenced by an …

[HTML][HTML] Human milk oligosaccharide consumption by probiotic and human-associated bifidobacteria and lactobacilli

T Thongaram, JL Hoeflinger, JM Chow, MJ Miller - Journal of dairy science, 2017 - Elsevier
Human milk contains high concentrations of nondigestible complex oligosaccharides
(human milk oligosaccharides; HMO) that reach the colon and are subsequently fermented …