Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

With more than ten new FDA approvals since 2001, peptides are emerging as an important
therapeutic alternative to small molecules. However, unlike small molecules, peptides on the …

Unlike natural macromolecules (eg, nucleic acids and proteins) possessing precisely
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …

Suitable labels are at the core of luminescence and fluorescence imaging and sensing. One
of the most exciting, yet also controversial, advances in label technology is the emerging …

Cell-penetrating peptides (CPPs) have been discovered to deliver chemical drugs, nucleic
acids, and macromolecules to permeate cell membranes, creating a novel route for …

All living systems require biochemical barriers. As a consequence, all drugs, imaging
agents, and probes have targets that are either on, in, or inside of these barriers. Fifteen …

Substrate-initiated, self-inactivating, cell-penetrating poly (disulfide) s (siCPDs) are
introduced as general transporters for the covalent delivery of unmodified substrates of free …

The ability of a drug or probe to cross a biological barrier has historically been viewed to be
a function of its intrinsic physical properties. This view has largely restricted drug design and …

Peptides including HIV-1 Tat peptide and oligoarginines represent arginine-rich membrane-
permeable vectors that attain efficient intracellular delivery of bioactive molecules. The …

Distance measurement in the nanometer range by electron paramagnetic resonance
spectroscopy (EPR) in combination with site-directed spin labeling is a very powerful tool to …