Brain tumors, particularly gliomas, remain difficult to treat due to their complex and dynamic
microenvironment and high mortality rate. The presence of tumor-associated macrophages …

Cervical cancer is the fourth most prevalent form of cancer affecting women, which poses a
significant concern, especially in middle-and lower-income countries with an approximately …

Lung cancer is among leading causes of death worldwide. The five-year survival rate of this
disease is extremely low (17.8%), mainly due to difficult early diagnosis and to the limited …

Lasso peptides are a class of ribosomally synthesized and post-translationally modified
peptides (RiPPs) defined by a macrolactam linkage between the N-terminus and the side …

As one of rare high-value ocotillol (OCT)-type ginsenosides, pseudoginsenoside Rt5 has
been identified with significant pharmacological activities. UDP-glycosyltransferases (UGTs) …

We currently lack antivirals for most human viruses. In a quest for new molecules, focusing
on viral RNA, instead of viral proteins, can represent a promising strategy. In this study, new …

The pKa value of a molecule is of interest to chemists across a broad spectrum of fields
including pharmacology, environmental chemistry and theoretical chemistry. Determination …

Escherichia coli possesses four initiator tRNA (i-tRNA) genes, three of which are present
together as metZWV and the fourth one as metY. In E. coli B, all four genes (metZWV and …

Cardiovascular diseases (CVDs) are significant causes of morbidity and mortality worldwide,
and pathological cardiac hypertrophy (PCH) is an essential predictor of many heart …

Cholinesterases are well‐known and widely studied enzymes crucial to human health and
involved in neurology, Alzheimer's, and lipid metabolism. The protonation pattern of active …