Haemodynamic forces influence the functional properties of vascular endothelium.
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …

Blood vessels are exposed to multiple mechanical forces that are exerted on the vessel wall
(radial, circumferential and longitudinal forces) or on the endothelial surface (shear stress) …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

PECAM-1 (also known as CD31) is a cellular adhesion and signaling receptor comprising
six extracellular immunoglobulin (Ig)-like homology domains, a short transmembrane …

Endothelial cells (ECs) form a unique barrier between the vascular lumen and the vascular
wall. In addition, the endothelium is highly metabolically active. In cardiovascular disease …

Different blood flow patterns in the arteries can alter the adaptive phenotype of vascular
endothelial cells (ECs), thereby affecting the functions of ECs and are directly associated …

Murine models of atherosclerosis are useful for investigating the environmental and genetic
influences on lesion formation and composition. Apoe−/− and Ldlr−/− mice are the 2 most …

The vascular endothelium is a highly specialized barrier that controls passage of fluids and
migration of cells from the lumen into the vessel wall. Endothelial cells assist leukocytes to …

Significance: Forces are important in the cardiovascular system, acting as regulators of
vascular physiology and pathology. Residing at the blood vessel interface, cells (endothelial …

Atherosclerosis is the leading cause of death worldwide and leukocyte recruitment is a key
element of this phenomenon, thus allowing immune cells to enter the arterial wall. There, in …