Effects of shear stress on endothelial cells: go with the flow
DA Chistiakov, AN Orekhov, YV Bobryshev - Acta physiologica, 2017 - Wiley Online Library
Haemodynamic forces influence the functional properties of vascular endothelium.
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …
Biomechanical factors in atherosclerosis: mechanisms and clinical implications
Blood vessels are exposed to multiple mechanical forces that are exerted on the vessel wall
(radial, circumferential and longitudinal forces) or on the endothelial surface (shear stress) …
(radial, circumferential and longitudinal forces) or on the endothelial surface (shear stress) …
Molecular biology of atherosclerosis
PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
[HTML][HTML] PECAM-1: regulator of endothelial junctional integrity
JR Privratsky, PJ Newman - Cell and tissue research, 2014 - Springer
PECAM-1 (also known as CD31) is a cellular adhesion and signaling receptor comprising
six extracellular immunoglobulin (Ig)-like homology domains, a short transmembrane …
six extracellular immunoglobulin (Ig)-like homology domains, a short transmembrane …
Endothelial barrier and its abnormalities in cardiovascular disease
DA Chistiakov, AN Orekhov, YV Bobryshev - Frontiers in physiology, 2015 - frontiersin.org
Endothelial cells (ECs) form a unique barrier between the vascular lumen and the vascular
wall. In addition, the endothelium is highly metabolically active. In cardiovascular disease …
wall. In addition, the endothelium is highly metabolically active. In cardiovascular disease …
[HTML][HTML] Effects of shear stress on vascular endothelial functions in atherosclerosis and potential therapeutic approaches
H Cheng, W Zhong, L Wang, Q Zhang, X Ma… - Biomedicine & …, 2023 - Elsevier
Different blood flow patterns in the arteries can alter the adaptive phenotype of vascular
endothelial cells (ECs), thereby affecting the functions of ECs and are directly associated …
endothelial cells (ECs), thereby affecting the functions of ECs and are directly associated …
Do the Apoe−/− and Ldlr−/– Mice Yield the Same Insight on Atherogenesis?
GS Getz, CA Reardon - Arteriosclerosis, thrombosis, and vascular …, 2016 - Am Heart Assoc
Murine models of atherosclerosis are useful for investigating the environmental and genetic
influences on lesion formation and composition. Apoe−/− and Ldlr−/− mice are the 2 most …
influences on lesion formation and composition. Apoe−/− and Ldlr−/− mice are the 2 most …
Endothelial barrier function and leukocyte transmigration in atherosclerosis
The vascular endothelium is a highly specialized barrier that controls passage of fluids and
migration of cells from the lumen into the vessel wall. Endothelial cells assist leukocytes to …
migration of cells from the lumen into the vessel wall. Endothelial cells assist leukocytes to …
Endothelial mechanosignaling: does one sensor fit all?
C Givens, E Tzima - Antioxidants & redox signaling, 2016 - liebertpub.com
Significance: Forces are important in the cardiovascular system, acting as regulators of
vascular physiology and pathology. Residing at the blood vessel interface, cells (endothelial …
vascular physiology and pathology. Residing at the blood vessel interface, cells (endothelial …
Where the action is—leukocyte recruitment in atherosclerosis
C Mauersberger, J Hinterdobler… - Frontiers in …, 2022 - frontiersin.org
Atherosclerosis is the leading cause of death worldwide and leukocyte recruitment is a key
element of this phenomenon, thus allowing immune cells to enter the arterial wall. There, in …
element of this phenomenon, thus allowing immune cells to enter the arterial wall. There, in …